CGP 52432, GABAB antagonist (ab120330)
Key features and details
- Potent GABAB antagonist
- CAS Number: 139667-74-6
- Soluble in water to 10 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
CGP 52432, GABAB antagonist -
Description
Potent GABAB antagonist -
Biological description
Potent, selective GABAB antagonist (IC50 = 85 nM).
Also available in simple stock solutions (ab146709) - add 1 ml of water to get an exact, ready-to-use concentration. -
CAS Number
139667-74-6 -
Chemical structure
Properties
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Chemical name
3-[[(3,4-Dichlorophenyl)methyl]amino]propyl(diethoxymethyl)phosphinic acid -
Molecular weight
384.24 -
Molecular formula
C15H24Cl2NO4P -
PubChem identifier
132252 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 10 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Clc1ccc(CNCCCP(=O)(O)C(OCC)OCC)cc1Cl -
Source
Synthetic
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Research areas
Images
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Chemical Structure - CGP 52432, GABAB antagonist (ab120330)2D chemical structure image of ab120330, CGP 52432, GABAB antagonist
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (10)
ab120330 has been referenced in 10 publications.
- Dorgans K et al. Short-term plasticity at cerebellar granule cell to molecular layer interneuron synapses expands information processing. Elife 8:N/A (2019). PubMed: 31081751
- Kim S et al. Dendritic spikes in hippocampal granule cells are necessary for long-term potentiation at the perforant path synapse. Elife 7:N/A (2018). PubMed: 29578411
- Minge D et al. Heparan Sulfates Support Pyramidal Cell Excitability, Synaptic Plasticity, and Context Discrimination. Cereb Cortex 27:903-918 (2017). PubMed: 28119345
- Schauer C et al. Hypothalamic gonadotropin-releasing hormone (GnRH) receptor neurons fire in synchrony with the female reproductive cycle. J Neurophysiol 114:1008-21 (2015). PubMed: 26063780
- Hernández VM et al. Parvalbumin+ Neurons and Npas1+ Neurons Are Distinct Neuron Classes in the Mouse External Globus Pallidus. J Neurosci 35:11830-47 (2015). PubMed: 26311767
- Hedrick T & Waters J Acetylcholine excites neocortical pyramidal neurons via nicotinic receptors. J Neurophysiol 113:2195-209 (2015). PubMed: 25589590
- Russo G et al. Dynamics of action potential firing in electrically connected striatal fast-spiking interneurons. Front Cell Neurosci 7:209 (2013). PubMed: 24294191
- Valera AM et al. Adaptation of granule cell to Purkinje cell synapses to high-frequency transmission. J Neurosci 32:3267-80 (2012). PubMed: 22378898
- Min R & Nevian T Astrocyte signaling controls spike timing-dependent depression at neocortical synapses. Nat Neurosci 15:746-53 (2012). PubMed: 22446881
- Brager DH et al. Impaired dendritic expression and plasticity of h-channels in the fmr1(-/y) mouse model of fragile X syndrome. Cell Rep 1:225-33 (2012). PubMed: 22662315
