For the best experience on the Abcam website please upgrade to a modern browser such as Google Chrome

Hello. We're improving abcam.com and we'd welcome your feedback.

Hello. We're improving abcam.com and we'd welcome your feedback.

Infomation icon

We haven't added this to the BETA yet

New BETA website

New BETA website

Hello. We're improving abcam.com and we'd welcome your feedback.

Take a look at our BETA site and see what we’ve done so far.

Switch on our new BETA site

Now available

Search and browse selected products

  • A selection of primary antibodies

Purchase these through your usual distributor

In the coming months

  • Additional product types
  • Supporting content
  • Sign in to your account
  • Purchase online
United States
Your country/region is currently set to:

If incorrect, please enter your country/region into the box below, to view site information related to your country/region.

Call (888) 77-ABCAM (22226) or contact us
Need help? Contact us

  • My account
  • Sign out
Sign in or Register with us

Welcome

Sign in or

Don't have an account?

Register with us
My basket
Quick order
Abcam homepage

  • Research Products
    By product type
    Primary antibodies
    Secondary antibodies
    ELISA and Matched Antibody Pair Kits
    Cell and tissue imaging tools
    Cellular and biochemical assays
    Proteins and Peptides
    By product type
    Proteomics tools
    Agonists, activators, antagonists and inhibitors
    Cell lines and Lysates
    Multiplex miRNA assays
    Multiplex Assays
    By research area
    Cancer
    Cardiovascular
    Cell Biology
    Epigenetics
    Metabolism
    Developmental Biology
    By research area
    Immunology
    Microbiology
    Neuroscience
    Signal Transduction
    Stem Cells
  • Customized Products & Partnerships
    Customized Products & Partnerships

    Customized products and commercial partnerships to accelerate your diagnostic and therapeutic programs.

    Customized products

    Partner with us

  • Support
    Support hub

    Access advice and support for any research roadblock

    View support hub

    Protocols

    Your experiments laid out step by step

    View protocols

  • Events
    • Conference calendar
    • Cancer
    • Cardiovascular
    • Epigenetics & Nuclear signaling
    • Immunology
    • Neuroscience
    • Stem cells
    • Tradeshows
    • Scientific webinars
    Keep up to date with the latest events

    Full event breakdown with abstracts, speakers, registration and more

    View global event calendar

  • Pathways
    Cell signalling pathways

    View all pathways

    View all interactive pathways

  1. Link

    products/biochemicals/cgp-55845-hydrochloride-gabab-antagonist-ab120337.pdf

  1. Send me a copy of this email
    I agree to the terms and conditions.
Neuroscience Neurotransmitter Amino Acids GABA
Share by email

CGP 55845 hydrochloride, GABAB antagonist (ab120337)

  • Datasheet
  • SDS
  • COA
Submit a review Q&A (1)References (29)

Product price, shipping and contact information

Currently unavailable

Sorry, we can't display this right now.

Please contact us to place your order, or try again later.

 

Loading size & price…

 

Shipping and order information

Shipping info

Promotion Information

Abpromise

Guaranteed product quality, expert customer support.

Find out more.

Chemical Structure - CGP 55845 hydrochloride, GABA<sub>B</sub> antagonist (ab120337)
  • Functional Studies - CGP 55845 hydrochloride, GABA<sub>B</sub> antagonist (ab120337)

Key features and details

  • Potent, selective GABAB antagonist
  • CAS Number: 149184-22-5
  • Soluble in DMSO to 100 mM
  • Form / State: Solid
  • Source: Synthetic

You may also be interested in

Biochemical
Product image
D-AP5, NMDA glutamate site antagonist (ab120003)
Primary
Product image
Anti-C2 antibody [EPR17979] (ab209900)
Protein
Recombinant human IL-13 protein (ab9577)

View more associated products

Overview

  • Product name

    CGP 55845 hydrochloride, GABAB antagonist
  • Description

    Potent, selective GABAB antagonist
  • Alternative names

    • CGP55845 hydrochloride
  • CAS Number

    149184-22-5
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    [(2S)-3-[[(1S)-1-(3,4-Dichlorophenyl)ethyl]amino]-2-hydroxypropyl](phenylmethyl)phosphinic acid hydrochloride
  • Molecular weight

    438.72
  • Molecular formula

    C18H22Cl2NO3P.HCl
  • PubChem identifier

    9954841
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C[C@@H](C1=CC(=C(C=C1)Cl)Cl)NC[C@@H](CP(=O)(CC2=CC=CC=C2)O)O.Cl
  • Source

    Synthetic

  • Research areas

    • Neuroscience
    • Neurotransmitter
    • Amino Acids
    • GABA
    • Biochemicals
    • Chemical Type
    • Biochemicals
    • Biochemicals
    • Pharmacology
    • Receptors & Transporters
    • GABA
    • GABAB
    • Biochemicals
    • Pharmacology
    • Receptors & Transporters
    • GABA
    • GABAB
    • Antagonists
    • Biochemicals
    • Research Area
    • Pain & inflammation
    • GABA
    • GABAB
    • Biochemicals
    • Research Area
    • Pain & inflammation
    • GABA
    • GABAB
    • Antagonists
    • Biochemicals
    • Research Area
    • Schizophrenia
    • GABA
    • GABAB
    • Biochemicals
    • Research Area
    • Schizophrenia
    • GABA
    • GABAB
    • Antagonists
    • Biochemicals
    • Research Area
    • Stress / Anxiety
    • GABA
    • GABAB
    • Biochemicals
    • Research Area
    • Stress / Anxiety
    • GABA
    • GABAB
    • Antagonists

Images

  • Chemical Structure - CGP 55845 hydrochloride, GABA<sub>B</sub> antagonist (ab120337)
    Chemical Structure - CGP 55845 hydrochloride, GABAB antagonist (ab120337)
    2D chemical structure image of ab120337, CGP 55845 hydrochloride, GABAB antagonist
  • Functional Studies - CGP 55845 hydrochloride, GABA<sub>B</sub> antagonist (ab120337)
    Functional Studies - CGP 55845 hydrochloride, GABAB antagonist (ab120337)Montalbano et al PLoS One. 2015 Oct 13;10(10):e0140369. doi: 10.1371/journal.pone.0140369. eCollection 2015. Fig 1. Reproduced under the Creative Commons license http://creativecommons.org/licenses/by/4.0/

    5-CT-activated inwardly rectifying K+ conductance in 5-HT neurons displays limited desensitization.

    (A) Time-course of a representative experiment (n = 6) showing the effect of increasing concentrations of bath applied 5-HT1A receptor agonist, 5-CT on inwardly rectifying K+ conductance (G-110/-90 mV) in a dorsal raphe 5-HT neuron. Extracellular solution contained 5.5 mM K+ and a mix of synaptic blockers (including ab120337). In this Fig time indicates duration of whole-cell configuration.

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

Datasheets and documents

  • SDS download

  • Datasheet download

    Download
  • COA

References (29)

Publishing research using ab120337? Please let us know so that we can cite the reference in this datasheet.

ab120337 has been referenced in 29 publications.

  • Zhang J  et al. Severe deficiency of the voltage-gated sodium channel NaV1.2 elevates neuronal excitability in adult mice. Cell Rep 36:109495 (2021). PubMed: 34348148
  • Booker SA  et al. Presynaptic GABAB receptors functionally uncouple somatostatin interneurons from the active hippocampal network. Elife 9:N/A (2020). PubMed: 32073397
  • Chittajallu R  et al. Activity-dependent tuning of intrinsic excitability in mouse and human neurogliaform cells. Elife 9:N/A (2020). PubMed: 32496194
  • Luo X  et al. Synaptic Mechanisms Underlying the Network State-Dependent Recruitment of VIP-Expressing Interneurons in the CA1 Hippocampus. Cereb Cortex 30:3667-3685 (2020). PubMed: 32080739
  • Rudolph S  et al. Cerebellum-Specific Deletion of the GABAA Receptor d Subunit Leads to Sex-Specific Disruption of Behavior. Cell Rep 33:108338 (2020). PubMed: 33147470
View all Publications for this product

Customer reviews and Q&As

Show All Reviews Q&A
Submit a review Submit a question

Question

Phone call requesting information about the solubility of CGP 55845 hydrochloride as the datasheet states solubility as 100 mM in DMSO whilst the CoA states 1 eq. of NaOH.

Read More

Abcam community

Verified customer

Asked on Feb 07 2012

Answer

Thank you for contacting us.


As discussed over the phone the solubility of CGP 55845 hydrochloride is 100 mM in DMSO. The information on the CoA was unfortunately an error. Thank you for bringing this to our attention. This will be altered to reflect the correct information.


I hope this information has been of help. If you require any further information please do nothesitate to contact us again.

Read More

Abcam Scientific Support

Answered on Feb 07 2012

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
For licensing inquiries, please contact partnerships@abcam.com

Get resources and offers direct to your inbox Sign up
A-Z by research area
  • Cancer
  • Cardiovascular
  • Cell biology
  • Developmental biology
  • Epigenetics & Nuclear signaling
  • Immunology
  • Metabolism
  • Microbiology
  • Neuroscience
  • Signal transduction
  • Stem cells
A-Z by product type
  • Primary antibodies
  • Secondary antibodies
  • Biochemicals
  • Isotype controls
  • Flow cytometry multi-color selector
  • Kits
  • Loading controls
  • Lysates
  • Peptides
  • Proteins
  • Slides
  • Tags and cell markers
  • Tools & Reagents
Help & support
  • Support
  • Make an Inquiry
  • Protocols & troubleshooting
  • Placing an order
  • RabMAb products
  • Biochemical product FAQs
  • Training
  • Browse by Target
Company
  • Corporate site
  • Investor relations
  • Company news
  • Careers
  • About us
  • Blog
Events
  • Tradeshows
  • Conferences
International websites
  • abcam.cn
  • abcam.co.jp

Join with us

  • LinkedIn
  • facebook
  • Twitter
  • YouTube
  • Terms of sale
  • Website terms of use
  • Cookie policy
  • Privacy policy
  • Legal
  • Modern slavery statement
© 1998-2023 Abcam plc. All rights reserved.