CGP 55845 hydrochloride, GABAB antagonist (ab120337)
Key features and details
- Potent, selective GABAB antagonist
- CAS Number: 149184-22-5
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
CGP 55845 hydrochloride, GABAB antagonist -
Description
Potent, selective GABAB antagonist -
Alternative names
- CGP55845 hydrochloride
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CAS Number
149184-22-5 -
Chemical structure
Properties
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Chemical name
[(2S)-3-[[(1S)-1-(3,4-Dichlorophenyl)ethyl]amino]-2-hydroxypropyl](phenylmethyl)phosphinic acid hydrochloride -
Molecular weight
438.72 -
Molecular formula
C18H22Cl2NO3P.HCl -
PubChem identifier
9954841 -
Storage instructions
Store at Room Temperature. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C[C@@H](C1=CC(=C(C=C1)Cl)Cl)NC[C@@H](CP(=O)(CC2=CC=CC=C2)O)O.Cl -
Source
Synthetic
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Research areas
Images
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Chemical Structure - CGP 55845 hydrochloride, GABAB antagonist (ab120337)2D chemical structure image of ab120337, CGP 55845 hydrochloride, GABAB antagonist
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Functional Studies - CGP 55845 hydrochloride, GABAB antagonist (ab120337)Montalbano et al PLoS One. 2015 Oct 13;10(10):e0140369. doi: 10.1371/journal.pone.0140369. eCollection 2015. Fig 1. Reproduced under the Creative Commons license http://creativecommons.org/licenses/by/4.0/5-CT-activated inwardly rectifying K+ conductance in 5-HT neurons displays limited desensitization.
(A) Time-course of a representative experiment (n = 6) showing the effect of increasing concentrations of bath applied 5-HT1A receptor agonist, 5-CT on inwardly rectifying K+ conductance (G-110/-90 mV) in a dorsal raphe 5-HT neuron. Extracellular solution contained 5.5 mM K+ and a mix of synaptic blockers (including ab120337). In this Fig time indicates duration of whole-cell configuration.
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (30)
ab120337 has been referenced in 30 publications.
- Mishra P & Narayanan R Conjunctive changes in multiple ion channels mediate activity-dependent intrinsic plasticity in hippocampal granule cells. iScience 25:103922 (2022). PubMed: 35252816
- Zhang J et al. Severe deficiency of the voltage-gated sodium channel NaV1.2 elevates neuronal excitability in adult mice. Cell Rep 36:109495 (2021). PubMed: 34348148
- Booker SA et al. Presynaptic GABAB receptors functionally uncouple somatostatin interneurons from the active hippocampal network. Elife 9:N/A (2020). PubMed: 32073397
- Chittajallu R et al. Activity-dependent tuning of intrinsic excitability in mouse and human neurogliaform cells. Elife 9:N/A (2020). PubMed: 32496194
- Luo X et al. Synaptic Mechanisms Underlying the Network State-Dependent Recruitment of VIP-Expressing Interneurons in the CA1 Hippocampus. Cereb Cortex 30:3667-3685 (2020). PubMed: 32080739