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    products/biochemicals/chaetocin-histone-lysine-methyltransferase-inhibitor-ab144534.pdf

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Chaetocin, histone lysine methyltransferase inhibitor (ab144534)

  • Datasheet
  • SDS
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Chemical Structure - Chaetocin, histone lysine methyltransferase inhibitor (ab144534)

    Key features and details

    • Lysine-specific methyltransferase inhibitor
    • CAS Number: 28097-03-2
    • Purity: > 98%
    • Soluble in DMSO to 10 mM
    • Form / State: Solid
    • Source: Synthetic

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    Overview

    • Product name

      Chaetocin, histone lysine methyltransferase inhibitor
    • Description

      Lysine-specific methyltransferase inhibitor
    • Purity

      > 98%
    • CAS Number

      28097-03-2
    • Chemical structure

      Chemical Structure

    Properties

    • Chemical name

      (3S,3'S,5aR,5aR,10bR,10'bR,11aS,11'aS)-2,2',3,3',5a,5'a,6,6'-Octahydro-3,3'-bis(hydroxymethyl)-2,2'-dimethyl-[10b,10'b(11H,11'H)-bi3,11a-epidithio-11aH-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole]-1,1',4,4'-tetrone
    • Molecular weight

      696.83
    • Molecular formula

      C30H28N6O6S4
    • PubChem identifier

      161591
    • Storage instructions

      Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
    • Solubility overview

      Soluble in DMSO to 10 mM
    • Handling

      Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

      Refer to SDS for further information.

      Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

    • SMILES

      CN1C(=O)C23CC4(C(N2C(=O)C1(SS3)CO)NC5=CC=CC=C54)C67CC89C(=O)N(C(C(=O)N8C6NC1=CC=CC=C71)(SS9)CO)C
    • Source

      Synthetic

    Images

    • Chemical Structure - Chaetocin, histone lysine methyltransferase inhibitor (ab144534)
      Chemical Structure - Chaetocin, histone lysine methyltransferase inhibitor (ab144534)
      2D chemical structure image of ab144534, Chaetocin, histone lysine methyltransferase inhibitor

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • SDS download

    • Datasheet download

      Download

    References (2)

    Publishing research using ab144534? Please let us know so that we can cite the reference in this datasheet.

    ab144534 has been referenced in 2 publications.

    • Harro CM  et al. Methyltransferase inhibitors restore SATB1 protective activity against cutaneous T cell lymphoma in mice. J Clin Invest 131:N/A (2021). PubMed: 33270606
    • Nakajima NI  et al. Inhibition of the HDAC/Suv39/G9a pathway restores the expression of DNA damage-dependent major histocompatibility complex class I-related chain A and B in cancer cells. Oncol Rep 38:693-702 (2017). PubMed: 28677817

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