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    products/biochemicals/ciglitazone-ppargamma-agonist-ab141139.pdf

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Cell Biology Cell Cycle Cell Cycle Inhibitors p53
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Ciglitazone, PPARgamma agonist (ab141139)

  • Datasheet
  • SDS
  • COA
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Chemical Structure - Ciglitazone, PPARgamma agonist (ab141139)
  • Functional Studies - Ciglitazone, PPARgamma agonist (ab141139)

Key features and details

  • Selective PPARγ agonist
  • CAS Number: 74772-77-3
  • Purity: > 98%
  • Soluble in DMSO to 100 mM and 1eq. NaOH to 100 mM
  • Form / State: Solid
  • Source: Synthetic

Overview

  • Product name

    Ciglitazone, PPARgamma agonist
  • Description

    Selective PPARγ agonist
  • Biological description

    Selective PPARγ agonist (EC50 = 3 µM). Shows antidiabetic and antineoplastic activity. Induces cell cycle arrest and apoptosis. Active in vivo.

  • Purity

    > 98%
  • CAS Number

    74772-77-3
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    5-[[4-[(1-Methylcyclohexyl)methoxy]phenyl]methyl]-2,4-thiazolidinedione
  • Molecular weight

    333.44
  • Molecular formula

    C18H23NO3S
  • PubChem identifier

    2750
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM and 1eq. NaOH to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Toxic, refer to SDS for further information

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1(CCCCC1)COc3ccc(CC2SC(=O)NC2=O)cc3
  • Source

    Synthetic

  • Research areas

    • Cell Biology
    • Cell Cycle
    • Cell Cycle Inhibitors
    • p53
    • Cell Biology
    • Apoptosis
    • Intracellular
    • p53 Pathway
    • Neuroscience
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    • GPCR
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    • GPCR
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    • Transcription
    • Cancer susceptibility
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    • Nuclear Receptors
    • Retinoic & Retinoid
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    • Cell cycle
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    • Transcription
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    • Biochemicals
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    • Obesity
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    • Heart disease
    • Biochemicals
    • Research Area
    • Cancer
    • Apoptosis & cell cycle
    • Other

Associated products

  • Related Products

    • PPAR gamma Transcription Factor Assay Kit (ab133101)
    • PPAR delta Transcription Factor Assay Kit (ab133106)
    • PPAR alpha Transcription Factor Assay Kit (ab133107)
    • PPAR (alpha, delta, gamma) Transcription Factor Assay Kit (ab133113)

Applications

The Abpromise guarantee

Our Abpromise guarantee covers the use of ab141139 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Functional Studies
Use at an assay dependent concentration.
Notes
Functional Studies
Use at an assay dependent concentration.

Images

  • Chemical Structure - Ciglitazone, PPARgamma agonist (ab141139)
    Chemical Structure - Ciglitazone, PPARgamma agonist (ab141139)
    2D chemical structure image of ab141139, Ciglitazone, PPARgamma agonist
  • Functional Studies - Ciglitazone, PPARgamma agonist (ab141139)
    Functional Studies - Ciglitazone, PPARgamma agonist (ab141139)
    ab19481 staining PPARγ in U-87 MG cells treated with ciglitazone (ab141139), by ICC/IF. Increase of PPARγ cytoplasmic expression correlates with increased concentration of ciglitazone, as described in literature.
    The cells were incubated at 37°C for 24 hours in media containing different concentrations of ab141139 (ciglitazone) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab19481 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

Datasheets and documents

  • SDS download

  • Datasheet download

    Download
  • COA

References (0)

Publishing research using ab141139? Please let us know so that we can cite the reference in this datasheet.

ab141139 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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