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    products/biochemicals/ck-666-actin-polymerization-inhibitor-ab141231.pdf

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Biochemicals Chemical Type Biochemicals
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CK 666, Actin polymerization inhibitor (ab141231)

  • Datasheet
  • SDS
  • COA
Submit a review Submit a question References (7)

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Chemical Structure - CK 666, Actin polymerization inhibitor (ab141231)

    Key features and details

    • Potent inhibitor of actin polymerization
    • CAS Number: 442633-00-3
    • Purity: > 99%
    • Soluble in DMSO to 100 mM and in ethanol to 100 mM
    • Form / State: Solid
    • Source: Synthetic

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    Overview

    • Product name

      CK 666, Actin polymerization inhibitor
    • Description

      Potent inhibitor of actin polymerization
    • Biological description

      Potent inhibitor of actin polymerization. Inhibits the Arp2/3 (IC50 = 17 μM), SpArp2/3 (IC50 = 5 μM) and HsArp2/3 complexes (IC50= 4 μM) by preventing a shift into an active conformation.

    • Purity

      > 99%
    • CAS Number

      442633-00-3
    • Chemical structure

      Chemical Structure

    Properties

    • Chemical name

      2-Fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]benzamide
    • Molecular weight

      296.34
    • Molecular formula

      C18H17FN2O
    • PubChem identifier

      589075
    • Storage instructions

      Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
    • Solubility overview

      Soluble in DMSO to 100 mM and in ethanol to 100 mM
    • Handling

      Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

      Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

    • SMILES

      Fc1ccccc1C(=O)NCCc2c3ccccc3nc2C
    • Source

      Synthetic

    • Research areas

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      • Actin

    Images

    • Chemical Structure - CK 666, Actin polymerization inhibitor (ab141231)
      Chemical Structure - CK 666, Actin polymerization inhibitor (ab141231)
      2D chemical structure image of ab141231, CK 666, Actin polymerization inhibitor

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • SDS download

    • Datasheet download

      Download
    • COA

    References (7)

    Publishing research using ab141231? Please let us know so that we can cite the reference in this datasheet.

    ab141231 has been referenced in 7 publications.

    • Rogerson C  et al. Akt1-associated actomyosin remodelling is required for nuclear lamina dispersal and nuclear shrinkage in epidermal terminal differentiation. Cell Death Differ 28:1849-1864 (2021). PubMed: 33462407
    • Noguchi Y  et al. Microscopic image-based covariation network analysis for actin scaffold-modified insulin signaling. iScience 24:102724 (2021). PubMed: 34337357
    • Rivers E  et al. Wiskott Aldrich syndrome protein regulates non-selective autophagy and mitochondrial homeostasis in human myeloid cells. Elife 9:N/A (2020). PubMed: 33135633
    • Randzavola LO  et al. Loss of ARPC1B impairs cytotoxic T lymphocyte maintenance and cytolytic activity. J Clin Invest 129:5600-5614 (2019). PubMed: 31710310
    • Dhanda AS  et al. Palladin Compensates for the Arp2/3 Complex and Supports Actin Structures during Listeria Infections. MBio 9:N/A (2018). PubMed: 29636431
    • Kruppa AJ  et al. Myosin VI-Dependent Actin Cages Encapsulate Parkin-Positive Damaged Mitochondria. Dev Cell 44:484-499.e6 (2018). PubMed: 29398621
    • Hanna SJ  et al. The Role of Rho-GTPases and actin polymerization during Macrophage Tunneling Nanotube Biogenesis. Sci Rep 7:8547 (2017). PubMed: 28819224

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