Key features and details
- Metabolite of Clozapine
- CAS Number: 34233-69-7
- Purity: > 99%
- Soluble in water to 100 mM
- Form / State: Solid
- Source: Synthetic
Product nameClozapine N-oxide, Metabolite of Clozapine
DescriptionMetabolite of Clozapine
Metabolite of atypical antipsychotic Clozapine (ab120019). Active in vitro and in vivo.
Chemical name8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e](1,4)diazepine N-oxide
Storage instructionsStore at Room Temperature. The product can be stored for up to 12 months.
Solubility overviewSoluble in water to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab141704 has been referenced in 21 publications.
- Tan N et al. Lateral Hypothalamus Calcium/Calmodulin-Dependent Protein Kinase II α Neurons Encode Novelty-Seeking Signals to Promote Predatory Eating. Research (Wash D C) 2022:9802382 (2022). PubMed: 36061821
- Zhao J et al. Activated astrocytes attenuate neocortical seizures in rodent models through driving Na+-K+-ATPase. Nat Commun 13:7136 (2022). PubMed: 36414629
- Takahashi TM et al. Optogenetic induction of hibernation-like state with modified human Opsin4 in mice. Cell Rep Methods 2:100336 (2022). PubMed: 36452866
- Horii-Hayashi N & Nishi M Protocol for behavioral tests using chemogenetically manipulated mice. STAR Protoc 2:100418 (2021). PubMed: 33899009
- Ma H et al. Amygdala-hippocampal innervation modulates stress-induced depressive-like behaviors through AMPA receptors. Proc Natl Acad Sci U S A 118:N/A (2021). PubMed: 33526688