Clozapine N-oxide, Metabolite of Clozapine (ab141704)
Key features and details
- Metabolite of Clozapine
- CAS Number: 34233-69-7
- Purity: > 99%
- Soluble in water to 100 mM
- Form / State: Solid
- Source: Synthetic
Product nameClozapine N-oxide, Metabolite of Clozapine
DescriptionMetabolite of Clozapine
Metabolite of atypical antipsychotic Clozapine (ab120019). Active in vitro and in vivo.
Chemical name8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e](1,4)diazepine N-oxide
Storage instructionsStore at Room Temperature. The product can be stored for up to 12 months.
Solubility overviewSoluble in water to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab141704 has been referenced in 17 publications.
- Horii-Hayashi N & Nishi M Protocol for behavioral tests using chemogenetically manipulated mice. STAR Protoc 2:100418 (2021). PubMed: 33899009
- Ma H et al. Amygdala-hippocampal innervation modulates stress-induced depressive-like behaviors through AMPA receptors. Proc Natl Acad Sci U S A 118:N/A (2021). PubMed: 33526688
- Biglari N et al. Functionally distinct POMC-expressing neuron subpopulations in hypothalamus revealed by intersectional targeting. Nat Neurosci 24:913-929 (2021). PubMed: 34002087
- Borgmann D et al. Gut-brain communication by distinct sensory neurons differently controls feeding and glucose metabolism. Cell Metab 33:1466-1482.e7 (2021). PubMed: 34043943
- Valyear MD et al. Dissociable mesolimbic dopamine circuits control responding triggered by alcohol-predictive discrete cues and contexts. Nat Commun 11:3764 (2020). PubMed: 32724058