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Biochemicals Product Range Just Add Water
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Clozapine N-oxide, Metabolite of Clozapine (ab141704)

  • Datasheet
  • SDS
  • COA
Reviews (1) Submit a question References (17)

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Chemical Structure - Clozapine N-oxide, Metabolite of Clozapine (ab141704)

    Key features and details

    • Metabolite of Clozapine
    • CAS Number: 34233-69-7
    • Purity: > 99%
    • Soluble in water to 100 mM
    • Form / State: Solid
    • Source: Synthetic

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    Overview

    • Product name

      Clozapine N-oxide, Metabolite of Clozapine
    • Description

      Metabolite of Clozapine
    • Biological description

      Metabolite of atypical antipsychotic Clozapine (ab120019). Active in vitro and in vivo.

    • Purity

      > 99%
    • CAS Number

      34233-69-7
    • Chemical structure

      Chemical Structure

    Properties

    • Chemical name

      8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e](1,4)diazepine N-oxide
    • Molecular weight

      342.83
    • Molecular formula

      C18H19ClN4O
    • PubChem identifier

      36727
    • Storage instructions

      Store at Room Temperature. The product can be stored for up to 12 months.
    • Solubility overview

      Soluble in water to 100 mM
    • Handling

      Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

      Toxic, refer to SDS for further information.

      Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

    • SMILES

      CN1CCN(CC1)C2=C3C=CC=CC3=NC4=C(N2O)C=C(C=C4)Cl
    • Source

      Synthetic

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    Associated products

    • Alternative Versions

      • Clozapine N-oxide, Metabolite of Clozapine (aqueous solution) (ab147474)

    Images

    • Chemical Structure - Clozapine N-oxide, Metabolite of Clozapine (ab141704)
      Chemical Structure - Clozapine N-oxide, Metabolite of Clozapine (ab141704)
      2D chemical structure image of ab141704, Clozapine N-oxide, Metabolite of Clozapine

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • SDS download

    • Datasheet download

      Download
    • COA

    References (17)

    Publishing research using ab141704? Please let us know so that we can cite the reference in this datasheet.

    ab141704 has been referenced in 17 publications.

    • Horii-Hayashi N & Nishi M Protocol for behavioral tests using chemogenetically manipulated mice. STAR Protoc 2:100418 (2021). PubMed: 33899009
    • Ma H  et al. Amygdala-hippocampal innervation modulates stress-induced depressive-like behaviors through AMPA receptors. Proc Natl Acad Sci U S A 118:N/A (2021). PubMed: 33526688
    • Biglari N  et al. Functionally distinct POMC-expressing neuron subpopulations in hypothalamus revealed by intersectional targeting. Nat Neurosci 24:913-929 (2021). PubMed: 34002087
    • Borgmann D  et al. Gut-brain communication by distinct sensory neurons differently controls feeding and glucose metabolism. Cell Metab 33:1466-1482.e7 (2021). PubMed: 34043943
    • Valyear MD  et al. Dissociable mesolimbic dopamine circuits control responding triggered by alcohol-predictive discrete cues and contexts. Nat Commun 11:3764 (2020). PubMed: 32724058
    View all Publications for this product

    Customer reviews and Q&As

    Show All Reviews Q&A
    Submit a review Submit a question

    N/A

    Excellent
    Abreviews
    Abreviews
    It goes into solution very fast, even in high osmotic solutions. Its fantastic!
    The reviewer received a reward from Abcam’s Loyalty Program in thanks for submitting this Abreview and for helping the scientific community make better-informed decisions.

    Abcam user community

    Verified customer

    Submitted Apr 01 2016

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