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    products/biochemicals/cytochalasin-b-actin-polymerization-inhibitor-ab143482.pdf

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Epigenetics and Nuclear Signaling DNA / RNA DNA Synthesis Topoisomerases
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Cytochalasin B, actin polymerization inhibitor (ab143482)

  • Datasheet
  • SDS
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Chemical Structure - Cytochalasin B, actin polymerization inhibitor (ab143482)

    Key features and details

    • Cell permeable actin polymerization inhibitor. Reversible KV1.5 blocker.
    • CAS Number: 14930-96-2
    • Purity: > 97%
    • Soluble in DMSO to 10 mM
    • Form / State: Solid
    • Source: Drechslera dematoidea

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    Overview

    • Product name

      Cytochalasin B, actin polymerization inhibitor
    • Description

      Cell permeable actin polymerization inhibitor. Reversible KV1.5 blocker.
    • Purity

      > 97%
    • CAS Number

      14930-96-2
    • Chemical structure

      Chemical Structure

    Properties

    • Chemical name

      (3E,5R,9R,11E,12aS,13S,15S,15aS,16S,18aS)-6,7,8,9,10,12a,13,14,15,15a,16,17-Dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-16-(phenylmethyl)-2H-oxacyclotetradecino[2,3-d]isoindole-2,18(5H)-dione
    • Molecular weight

      479.61
    • Molecular formula

      C29H37NO5
    • PubChem identifier

      5311281
    • Storage instructions

      Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
    • Solubility overview

      Soluble in DMSO to 10 mM
    • Handling

      Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

      Toxic, refer to SDS for further information.

      Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

    • SMILES

      C[C@@H]1CCC[C@@H](/C=C/C(=O)O[C@]23[C@@H](/C=C/C1)[C@@H](C(=C)[C@H]([C@H]2[C@@H](NC3=O)Cc4ccccc4)C)O)O
    • Source

      Drechslera dematoidea

    • Research areas

      • Epigenetics and Nuclear Signaling
      • DNA / RNA
      • DNA Synthesis
      • Topoisomerases
      • Signal Transduction
      • Metabolism
      • Energy Metabolism
      • Cancer
      • Cancer Metabolism
      • Metabolic signaling pathway
      • Metabolism of lipids and lipoproteins
      • Biochemicals
      • Chemical Type
      • Biochemicals
      • Biochemicals
      • Pharmacology
      • Ion Channels
      • Potassium
      • Blockers
      • Metabolism
      • Pathways and Processes
      • Metabolic signaling pathways
      • Lipid and lipoprotein metabolism
      • Lipid metabolism
      • Metabolism
      • Pathways and Processes
      • Metabolic signaling pathways
      • Energy transfer pathways
      • Energy Metabolism
      • Biochemicals
      • Pharmacology
      • Signaling
      • Cytoskeleton & motor proteins
      • Actin

    Images

    • Chemical Structure - Cytochalasin B, actin polymerization inhibitor (ab143482)
      Chemical Structure - Cytochalasin B, actin polymerization inhibitor (ab143482)
      2D chemical structure image of ab143482, Cytochalasin B, actin polymerization inhibitor

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • SDS download

    • Datasheet download

      Download

    References (2)

    Publishing research using ab143482? Please let us know so that we can cite the reference in this datasheet.

    ab143482 has been referenced in 2 publications.

    • Wang F  et al. MICAL2PV suppresses the formation of tunneling nanotubes and modulates mitochondrial trafficking. EMBO Rep 22:e52006 (2021). PubMed: 34096155
    • Takahashi K  et al. In vitro rejuvenation of brain mitochondria by the inhibition of actin polymerization. Sci Rep 8:15585 (2018). PubMed: 30348987

    Customer reviews and Q&As

    Show All Reviews Q&A
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    CB addition can significantly improve pig embryo developmet

    Excellent
    Abreviews
    Abreviews
    abreview image
    CB addition can significantly improve pig embryo developmet,and the blastcysts rate can improve a lot.
    The reviewer received a reward from Abcam’s Loyalty Program in thanks for submitting this Abreview and for helping the scientific community make better-informed decisions.

    Abcam user community

    Verified customer

    Submitted Nov 25 2021

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