Cytochalasin B, actin polymerization inhibitor (ab143482)
Key features and details
- Cell permeable actin polymerization inhibitor. Reversible KV1.5 blocker.
- CAS Number: 14930-96-2
- Purity: > 97%
- Soluble in DMSO to 10 mM
- Form / State: Solid
- Source: Drechslera dematoidea
Overview
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Product name
Cytochalasin B, actin polymerization inhibitor -
Description
Cell permeable actin polymerization inhibitor. Reversible KV1.5 blocker. -
Purity
> 97% -
CAS Number
14930-96-2 -
Chemical structure
Properties
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Chemical name
(3E,5R,9R,11E,12aS,13S,15S,15aS,16S,18aS)-6,7,8,9,10,12a,13,14,15,15a,16,17-Dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-16-(phenylmethyl)-2H-oxacyclotetradecino[2,3-d]isoindole-2,18(5H)-dione -
Molecular weight
479.61 -
Molecular formula
C29H37NO5 -
PubChem identifier
5311281 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 10 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C[C@@H]1CCC[C@@H](/C=C/C(=O)O[C@]23[C@@H](/C=C/C1)[C@@H](C(=C)[C@H]([C@H]2[C@@H](NC3=O)Cc4ccccc4)C)O)O -
Source
Drechslera dematoidea
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Research areas
Images
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Chemical Structure - Cytochalasin B, actin polymerization inhibitor (ab143482)2D chemical structure image of ab143482, Cytochalasin B, actin polymerization inhibitor
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (2)
ab143482 has been referenced in 2 publications.
- Wang F et al. MICAL2PV suppresses the formation of tunneling nanotubes and modulates mitochondrial trafficking. EMBO Rep 22:e52006 (2021). PubMed: 34096155
- Takahashi K et al. In vitro rejuvenation of brain mitochondria by the inhibition of actin polymerization. Sci Rep 8:15585 (2018). PubMed: 30348987