Key features and details
- Potent and selective μ opioid receptor agonist
- CAS Number: 78123-71-4
- Purity: > 95%
- Soluble in water to 1 mg/ml
- Form / State: Solid
- Source: Synthetic
Product nameDAMGO, mu opioid receptor agonist
DescriptionPotent and selective μ opioid receptor agonist
Potent and selective μ opioid receptor agonist (Ki values are 2.0, >1000 and >1000 nM for opioid receptor subtypes μ, κ and δ, respectively). Partial central activity following systemic administration. Antinociceptive.
SequenceYAGFG (Modifications: C-terminal alcohol; Ala-2 = D-Ala; Phe-4 = N-Me)
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in water to 1 mg/ml
This product is supplied in one (or more) pack size which is freeze dried. Therefore the contents may not be readily visible, as they can coat the bottom or walls of the vial. Please see our FAQs and information page for more details on handling.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab120674 has been referenced in 4 publications.
- Wei XP et al. A novel reticular node in the brainstem synchronizes neonatal mouse crying with breathing. Neuron 110:644-657.e6 (2022). PubMed: 34998469
- Copits BA et al. A photoswitchable GPCR-based opsin for presynaptic inhibition. Neuron 109:1791-1809.e11 (2021). PubMed: 33979635
- Bachmutsky I et al. Opioids depress breathing through two small brainstem sites. Elife 9:N/A (2020). PubMed: 32073401
- Bull FA et al. Morphine activation of mu opioid receptors causes disinhibition of neurons in the ventral tegmental area mediated by ß-arrestin2 and c-Src. Sci Rep 7:9969 (2017). PubMed: 28855588