DL-AP5, NMDA glutamate site antagonist (ab120004)
Key features and details
- NMDA glutamate site antagonist
- CAS Number: 76326-31-3
- Soluble in water to 25 mM and in 1 eq. NaOH to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
DL-AP5, NMDA glutamate site antagonist -
Description
NMDA glutamate site antagonist -
Biological description
Competitive NMDA receptor glutamate site antagonist. Also available as the sodium salt (ab120271).
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CAS Number
76326-31-3 -
Chemical structure
Properties
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Chemical name
DL-2-Amino-5-phosphonopentanoic acid -
Molecular weight
197.13 -
Molecular formula
C5H12NO5P -
PubChem identifier
1216 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 25 mM and in 1 eq. NaOH to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
NC(CCCP(=O)(O)O)C(=O)O -
Source
Synthetic
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Research areas
Images
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Chemical Structure - DL-AP5, NMDA glutamate site antagonist (ab120004)2D chemical structure image of ab120004, DL-AP5, NMDA glutamate site antagonist
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (80)
ab120004 has been referenced in 80 publications.
- Asgarihafshejani A et al. Long-term potentiation at pyramidal cell to somatostatin interneuron synapses controls hippocampal network plasticity and memory. iScience 25:104259 (2022). PubMed: 35521524
- Zaccard CR et al. Protocol for live enhanced resolution confocal imaging of dendritic spinule dynamics in primary mouse cortical neuron culture. STAR Protoc 2:100427 (2021). PubMed: 33899014
- Zaccard CR et al. Rapid 3D Enhanced Resolution Microscopy Reveals Diversity in Dendritic Spinule Dynamics, Regulation, and Function. Neuron 107:522-537.e6 (2020). PubMed: 32464088
- Erli F et al. Estradiol reverses excitatory synapse loss in a cellular model of neuropsychiatric disorders. Transl Psychiatry 10:16 (2020). PubMed: 32066698
- Sahu G et al. Junctophilin Proteins Tether a Cav1-RyR2-KCa3.1 Tripartite Complex to Regulate Neuronal Excitability. Cell Rep 28:2427-2442.e6 (2019). PubMed: 31461656