Domperidone, Peripheral D2-like receptor antagonist (ab120566)
Key features and details
- Peripheral D2-like receptor antagonist
- CAS Number: 57808-66-9
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
-
Product name
Domperidone, Peripheral D2-like receptor antagonist -
Description
Peripheral D2-like receptor antagonist -
Biological description
Peripheral D2-like receptor antagonist. Does not readily cross the blood-brain barrier, and displays gastrokinetic and antiemetic properties.
-
CAS Number
57808-66-9 -
Chemical structure
Properties
-
Chemical name
5-Chloro-1-[1-[3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl]-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one -
Molecular weight
425.92 -
Molecular formula
C22H24ClN5O2 -
PubChem identifier
3151 -
Storage instructions
Store at Room Temperature. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
-
SMILES
Clc4cc5NC(=O)N(C3CCN(CCCN1c2ccccc2NC1=O)CC3)c5cc4 -
Source
Synthetic
-
Research areas
- Signal Transduction
- Signaling Pathway
- Nuclear Signaling
- Nuclear Hormone Receptors
- Retinoic & Retinoid
- Epigenetics and Nuclear Signaling
- Nuclear Signaling Pathways
- Nuclear Receptors
- Orphan Nuclear Receptors
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Nucleotide metabolism
- Molecular processes
- Mitochondrial transcription
Images
-
Chemical Structure - Domperidone, Peripheral D2-like receptor antagonist (ab120566)2D chemical structure image of ab120566, Domperidone, Peripheral D2-like receptor antagonist
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (1)
ab120566 has been referenced in 1 publication.
- Romanò N et al. Plasticity of hypothalamic dopamine neurons during lactation results in dissociation of electrical activity and release. J Neurosci 33:4424-33 (2013). PubMed: 23467359