Endothelin-1 (human, porcine), Vasoconstrictor peptide (ab120471)
Key features and details
- Vasoconstrictor peptide
- CAS Number: 117399-94-7
- Soluble in 1% acetic acid to 1mg/ml
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Endothelin-1 (human, porcine), Vasoconstrictor peptide -
Description
Vasoconstrictor peptide -
Biological description
Endogenous agonist at ETA and ETB receptors. Potent vasoconstrictor peptide involved in modulating vascular tone.
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CAS Number
117399-94-7 -
Chemical structure
Properties
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Molecular weight
2491.90 -
Molecular formula
C109H159N25O32S5 -
Sequence
CSCSSLMDKECVYFCHLDIIW (Modifications: Disulfide bonds: 1-15, 3-11) -
PubChem identifier
16133807 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in 1% acetic acid to 1mg/ml -
Handling
This product is supplied in one (or more) pack size which is freeze dried. Therefore the contents may not be readily visible, as they can coat the bottom or walls of the vial. Please see our FAQs and information page for more details on handling.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC[C@H](C)[C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC2=CC=CC=C21)C(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC3=CNC=N3)NC(=O)[C@@H]4CSSC[C@@H](C(=O)N[C@H](C(=O)N[C@H]5CSSC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N4)CC6=CC=CC=C6)CC7=CC=C(C=C7)O)C(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC5=O)CO)CO)CC(C)C)CCSC)CC(=O)O)CCCCN)CCC(=O)O)CO)N -
Source
Synthetic
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Research areas
Images
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Chemical Structure - Endothelin-1 (human, porcine), Vasoconstrictor peptide (ab120471)2D chemical structure image of ab120471, Endothelin-1 (human, porcine), Vasoconstrictor peptide
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (7)
ab120471 has been referenced in 7 publications.
- Cappelli J et al. Glycine-induced NMDA receptor internalization provides neuroprotection and preserves vasculature following ischemic stroke. iScience 25:103539 (2022). PubMed: 34977503
- Schuch CP et al. An RFID-based activity tracking system to monitor individual rodent behavior in environmental enrichment: Implications for post-stroke cognitive recovery. J Neurosci Methods 324:108306 (2019). PubMed: 31152754
- Obermeyer JM et al. Local Delivery of Brain-Derived Neurotrophic Factor Enables Behavioral Recovery and Tissue Repair in Stroke-Injured Rats. Tissue Eng Part A 25:1175-1187 (2019). PubMed: 30612516
- Sander KN et al. Pharmacological profile of vascular activity of human stem villous arteries. Placenta 88:12-19 (2019). PubMed: 31574379
- Balbinot G et al. Post-stroke kinematic analysis in rats reveals similar reaching abnormalities as humans. Sci Rep 8:8738 (2018). PubMed: 29880827
- Jeffers MS et al. Does Stroke Rehabilitation Really Matter? Part B: An Algorithm for Prescribing an Effective Intensity of Rehabilitation. Neurorehabil Neural Repair 32:73-83 (2018). PubMed: 29334831
- Jeffers MS & Corbett D Synergistic Effects of Enriched Environment and Task-Specific Reach Training on Poststroke Recovery of Motor Function. Stroke 49:1496-1503 (2018). PubMed: 29752347