Epoxomicin, 20S proteasome inhibitor (ab144598)
Key features and details
- Potent, selective, irreversible and cell-permeable 20S proteasome inhibitor
- CAS Number: 134381-21-8
- Purity: > 97%
- Soluble in DMSO to 10 mM
- Form / State: Solid
- Source: Actinomyces sp.
Overview
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Product name
Epoxomicin, 20S proteasome inhibitor -
Description
Potent, selective, irreversible and cell-permeable 20S proteasome inhibitor -
Biological description
Potent, selective, irreversible and cell-permeable 20S proteasome inhibitor (IC50 = 4 nM). Predominantly inhibits the chymotrypsin-like activity. Anti-inflammatory and antitumor agent. Active in vitro and in vivo. -
Purity
> 97% -
CAS Number
134381-21-8 -
Chemical structure
Properties
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Chemical name
N-Acetyl-N-methyl-L-isoleucyl-L-isoleucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyloxiranyl]carbonyl]butyl]-L-threoninamide -
Molecular weight
554.73 -
Molecular formula
C28H50N4O7 -
PubChem identifier
3035402 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 10 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CCC(C)C(C(=O)NC(=O)C(C(C)O)NC(CC(C)C)C(=O)C1(CO1)C)NC(=O)C(C(C)CC)N(C)C(=O)C -
Source
Actinomyces sp.
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Research areas
Images
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Chemical Structure - Epoxomicin, 20S proteasome inhibitor (ab144598)2D chemical structure image of ab144598, Epoxomicin, 20S proteasome inhibitor
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (4)
ab144598 has been referenced in 4 publications.
- Cassioli C et al. The Bardet-Biedl syndrome complex component BBS1 controls T cell polarity during immune synapse assembly. J Cell Sci 134:N/A (2021). PubMed: 34423835
- Cassioli C et al. The Bardet-Biedl syndrome complex component BBS1 controls T cell polarity during immune synapse assembly. J Cell Sci N/A:N/A (2021). PubMed: 34251457
- Ren D et al. Wnt5a induces and maintains prostate cancer cells dormancy in bone. J Exp Med 216:428-449 (2019). PubMed: 30593464
- Onnis A et al. The pro-oxidant adaptor p66SHC promotes B cell mitophagy by disrupting mitochondrial integrity and recruiting LC3-II. Autophagy 14:2117-2138 (2018). PubMed: 30109811