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    products/biochemicals/flufenamic-acid-cox-inhibitor-ab120354.pdf

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Flufenamic acid, COX inhibitor (ab120354)

  • Datasheet
  • SDS
  • COA
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Chemical Structure - Flufenamic acid, COX inhibitor (ab120354)
  • Functional Studies - Flufenamic acid, COX inhibitor (ab120354)

Key features and details

  • NSAID. COX inhibitor, channel blocker.
  • CAS Number: 530-78-9
  • Soluble in DMSO to 100 mM and in ethanol to 100 mM
  • Form / State: Solid
  • Source: Synthetic

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Overview

  • Product name

    Flufenamic acid, COX inhibitor
  • Description

    NSAID. COX inhibitor, channel blocker.
  • Biological description

    Non-steroidal anti-inflammatory. Potently inhibits human transthyretin amyloid fibril formation. Alters ion fluxes through the plasma membrane. Potent non-specific blocker of cation and anion channels, commonly used to block currents through TRP channels and receptor-operated channels.

  • CAS Number

    530-78-9
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2-[3-(Trifluoromethyl)phenylamino]benzoic acid
  • Molecular weight

    281.23
  • Molecular formula

    C14H10F3NO2
  • PubChem identifier

    3371
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM and in ethanol to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Toxic, refer to SDS for further information.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    FC(F)(F)c1cc(ccc1)Nc2ccccc2C(=O)O
  • Source

    Synthetic

  • Research areas

    • Cell Biology
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Applications

The Abpromise guarantee

Our Abpromise guarantee covers the use of ab120354 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Functional Studies
Use at an assay dependent concentration.
Notes
Functional Studies
Use at an assay dependent concentration.

Images

  • Chemical Structure - Flufenamic acid, COX inhibitor (ab120354)
    Chemical Structure - Flufenamic acid, COX inhibitor (ab120354)
    2D chemical structure image of ab120354, Flufenamic acid, COX inhibitor
  • Functional Studies - Flufenamic acid, COX inhibitor (ab120354)
    Functional Studies - Flufenamic acid, COX inhibitor (ab120354)
    ab51110 staining AMPKα 1 + AMPKα 2 (phosphoT172) in HeLa cells treated with flufenamic acid (ab120354), by ICC/IF. Increase in AMPKα 1 + AMPKα 2 (phosphoT172) nuclear expression correlates with increased concentration of flufenamic acid, as described in literature.
    The cells were incubated at 37°C for 30 minutes in media containing different concentrations of ab120354 (flufenamic acid) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab51110 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody.

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

Datasheets and documents

  • SDS download

  • Datasheet download

    Download
  • COA

References (2)

Publishing research using ab120354? Please let us know so that we can cite the reference in this datasheet.

ab120354 has been referenced in 2 publications.

  • Sui S  et al. iPSC-Derived Trabecular Meshwork Cells Stimulate Endogenous TM Cell Division Through Gap Junction in a Mouse Model of Glaucoma. Invest Ophthalmol Vis Sci 62:28 (2021). PubMed: 34427623
  • Rhett JM  et al. Connexin-Based Therapeutics and Tissue Engineering Approaches to the Amelioration of Chronic Pancreatitis and Type I Diabetes: Construction and Characterization of a Novel Prevascularized Bioartificial Pancreas. J Diabetes Res 2016:7262680 (2016). PubMed: 26788521

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