Key features and details
- Highly selective, potent, competitive ETA receptor antagonist
- CAS Number: 142375-60-8
- Purity: > 98%
- Soluble in ethanol to 100 mM, in DMSO to 100 mM and in 1eq. HCl to 100 mM.
- Form / State: Solid
- Source: Synthetic
Product nameFR 139317, ETA receptor antagonist
DescriptionHighly selective, potent, competitive ETA receptor antagonist
Highly selective, potent, competitive ETA receptor antagonist (Ki values are 1 nM and 7.3 μM for ETA and ETB, respectively). Inhibits endothelin-1-induced vasoconstriction in vivo.
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in ethanol to 100 mM, in DMSO to 100 mM and in 1eq. HCl to 100 mM.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab144636 has not yet been referenced specifically in any publications.