GF 109203X (Bisindolylmaleimide i), PKC inhibitor (ab144264)
Key features and details
- Potent, selective PKC inhibitor. Potent GSK-3 inhibitor. Potent 5-HT3 antagonist.
- CAS Number: 133052-90-1
- Purity: > 98%
- Soluble in DMSO to 25 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
GF 109203X (Bisindolylmaleimide i), PKC inhibitor -
Description
Potent, selective PKC inhibitor. Potent GSK-3 inhibitor. Potent 5-HT3 antagonist. -
Alternative names
- Bisindolylmaleimide I
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Purity
> 98% -
CAS Number
133052-90-1 -
Chemical structure
Properties
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Chemical name
3-[1-[3-(Dimethylamino)propyl]indol-3-yl]-4-(1H-indol-3-yl)pyrrole-2,5-dione -
Molecular weight
412.48 -
Molecular formula
C25H24N4O2 -
PubChem identifier
2396 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 25 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CN(C)CCCN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=CNC5=CC=CC=C54 -
Source
Synthetic
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Research areas
Images
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Chemical Structure - GF 109203X (Bisindolylmaleimide i), PKC inhibitor (ab144264)2D chemical structure image of ab144264, GF 109203X (Bisindolylmaleimide i), PKC inhibitor
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Functional Studies - GF 109203X (Bisindolylmaleimide i), PKC inhibitor (ab144264)1.5 x 10e7 THP-1 cells were incubated with 100 nM GF 109203X (ab144264) or Ro 31-8220 mesylate (ab120374) for 30 minutes prior to activation with 10 µg x mL-1 PMA (Sigma) for 4 hours. Control cells were left without inhibitors or PMA. Cells were lysed in 1 mL of lysis buffer, and 30 µL were tested for PKC activity (duplicates; +/- SD).
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (2)
ab144264 has been referenced in 2 publications.
- Wu K et al. Activity- and sleep-dependent regulation of tonic inhibition by Shisa7. Cell Rep 34:108899 (2021). PubMed: 33761345
- Sutherland-Deveen ME et al. Differential Regulation of Human Ether-à-Go-Go-Related Gene (hERG) Current and Expression by Activation of Protein Kinase C. Mol Pharmacol 96:1-12 (2019). PubMed: 31015282