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    products/biochemicals/glibenclamide-glyburide-k-channel-blocker-ab120267.pdf

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Neuroscience Neurotransmission Receptors / Channels Potassium Channels
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Glibenclamide (Glyburide), K+ channel blocker (ab120267)

  • Datasheet
  • SDS
  • COA
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Chemical Structure - Glibenclamide (Glyburide), K<sup>+</sup> channel blocker (ab120267)
  • Functional Studies - Glibenclamide (Glyburide), K<sup>+</sup> channel blocker (ab120267)

Key features and details

  • K+ channel blocker
  • CAS Number: 10238-21-8
  • Soluble in DMSO to 100 mM
  • Form / State: Solid
  • Source: Synthetic

Overview

  • Product name

    Glibenclamide (Glyburide), K+ channel blocker
  • Description

    K+ channel blocker
  • Alternative names

    • Glyburide
  • Biological description

    Selective blocker of ATP-sensitive (KIR6.x) inward rectifier K+ channels.

  • CAS Number

    10238-21-8
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    N-p-[2-(5-Chloro-2-methoxybenzamido)ethyl]benzenesulfonyl-N'-cyclohexylurea
  • Molecular weight

    494.00
  • Molecular formula

    C23H28ClN3O5S
  • PubChem identifier

    3488
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Refer to SDS for further information

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    O=C(NC1CCCCC1)NS(=O)(=O)c3ccc(CCNC(=O)c2cc(Cl)ccc2OC)cc3
  • Source

    Synthetic

  • Research areas

    • Neuroscience
    • Neurotransmission
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    • Potassium Channels
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    • Innate Immunity
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    • Lipids / Lipoproteins
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    • Signal Transduction
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    • Hormones
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    • Tags & Cell Markers
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    • Channels
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    • Epigenetics and Nuclear Signaling
    • Transcription
    • Transcription Factors
    • Epigenetics and Nuclear Signaling
    • Nuclear Signaling Pathways
    • Nuclear Receptors
    • Orphan Nuclear Receptors
    • Signal Transduction
    • Metabolism
    • Lipid metabolism
    • Signal Transduction
    • Metabolism
    • Drug metabolism
    • Cardiovascular
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    • Blockers
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    • Research Area
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    • Research Area
    • Stroke
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Applications

The Abpromise guarantee

Our Abpromise guarantee covers the use of ab120267 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Functional Studies
Use at an assay dependent concentration.
Notes
Functional Studies
Use at an assay dependent concentration.

Images

  • Chemical Structure - Glibenclamide (Glyburide), K<sup>+</sup> channel blocker (ab120267)
    Chemical Structure - Glibenclamide (Glyburide), K+ channel blocker (ab120267)
    2D chemical structure image of ab120267, Glibenclamide (Glyburide), K+ channel blocker
  • Functional Studies - Glibenclamide (Glyburide), K<sup>+</sup> channel blocker (ab120267)
    Functional Studies - Glibenclamide (Glyburide), K+ channel blocker (ab120267)

    MEF1 cells were incubated at 37°C for 24h with vehicle control (0 µM) and 5 µM of glibenclamide (ab120267) in DMSO. Increased expression of JNK1+JNK2 (phospho T183 + Y185) (ab4821) correlates with an increase in glibenclamide concentration, as described in literature.

    Whole cell lysates were prepared with RIPA buffer (containing protease inhibitors and sodium orthovanadate), 10 µg of each were loaded on the gel and the WB was run under reducing conditions. After transfer the membrane was blocked for an hour using 3% milk before being incubated with ab4821at 1/1000 dilution and ab85139 at 1 µg/ml overnight at 4°C. Antibody binding was detected using an anti-rabbit antibody conjugated to HRP (ab97051) at 1/10000 dilution and visualised using ECL development solution.

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

Datasheets and documents

  • SDS download

  • Datasheet download

    Download
  • COA

References (2)

Publishing research using ab120267? Please let us know so that we can cite the reference in this datasheet.

ab120267 has been referenced in 2 publications.

  • Wilkinson CM  et al. Glibenclamide, a Sur1-Trpm4 antagonist, does not improve outcome after collagenase-induced intracerebral hemorrhage. PLoS One 14:e0215952 (2019). PubMed: 31042750
  • Bragança B  et al. Ion Fluxes through KCa2 (SK) and Cav1 (L-type) Channels Contribute to Chronoselectivity of Adenosine A1 Receptor-Mediated Actions in Spontaneously Beating Rat Atria. Front Pharmacol 7:45 (2016). PubMed: 27014060

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