Harringtonine, translational protein synthesis inhibitor (ab141941)
Key features and details
- Translational protein synthesis inhibitor
- CAS Number: 26833-85-2
- Purity: > 95%
- Soluble in DMSO to 100 mM and in ethanol to 50 mM
- Form / State: Solid
- Source: Cephalotaxus harringtonia
Overview
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Product name
Harringtonine, translational protein synthesis inhibitor -
Description
Translational protein synthesis inhibitor -
Purity
> 95% -
CAS Number
26833-85-2 -
Chemical structure
Properties
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Chemical name
3-[4-Methyl (2R)-2-hydroxy-2-(3-hydroxy-3-methylbutyl)butanedioate]cephalotaxine -
Molecular weight
531.60 -
Molecular formula
C28H37NO9 -
PubChem identifier
29927670 -
Storage instructions
Store at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions. -
Solubility overview
Soluble in DMSO to 100 mM and in ethanol to 50 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC(C)(CCC(CC(=O)OC)(C(=O)OC1C2C3=CC4=C(C=C3CCN5C2(CCC5)C=C1OC)OCO4)O)O -
Source
Cephalotaxus harringtonia
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Research areas
Images
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Chemical Structure - Harringtonine, translational protein synthesis inhibitor (ab141941)2D chemical structure image of ab141941, Harringtonine, translational protein synthesis inhibitor
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (10)
ab141941 has been referenced in 10 publications.
- Cheng R et al. A novel protein RASON encoded by a lncRNA controls oncogenic RAS signaling in KRAS mutant cancers. Cell Res 33:30-45 (2023). PubMed: 36241718
- Kriachkov V et al. Arginine-rich C9ORF72 ALS proteins stall ribosomes in a manner distinct from a canonical ribosome-associated quality control substrate. J Biol Chem 299:102774 (2023). PubMed: 36481270
- Chern T et al. Mutations in Hcfc1 and Ronin result in an inborn error of cobalamin metabolism and ribosomopathy. Nat Commun 13:134 (2022). PubMed: 35013307
- Cheng LC et al. Alternative 3' UTRs play a widespread role in translation-independent mRNA association with the endoplasmic reticulum. Cell Rep 36:109407 (2021). PubMed: 34289366
- Martinez TF et al. Accurate annotation of human protein-coding small open reading frames. Nat Chem Biol 16:458-468 (2020). PubMed: 31819274
- Takahashi K et al. Critical Roles of Translation Initiation and RNA Uridylation in Endogenous Retroviral Expression and Neural Differentiation in Pluripotent Stem Cells. Cell Rep 31:107715 (2020). PubMed: 32492424
- Argüello RJ et al. SCENITH: A Flow Cytometry-Based Method to Functionally Profile Energy Metabolism with Single-Cell Resolution. Cell Metab 32:1063-1075.e7 (2020). PubMed: 33264598
- Argüello RJ et al. SunRiSE - measuring translation elongation at single-cell resolution by means of flow cytometry. J Cell Sci 131:N/A (2018). PubMed: 29700204
- Simsek D et al. The Mammalian Ribo-interactome Reveals Ribosome Functional Diversity and Heterogeneity. Cell 169:1051-1065.e18 (2017). PubMed: 28575669
- Tsokanos FF et al. eIF4A inactivates TORC1 in response to amino acid starvation. EMBO J 35:1058-76 (2016). PubMed: 26988032