Heptelidic acid (Koningic acid), GAPDH inhibitor (ab144269)
Key features and details
- Potent, selective, irreversible GAPDH inhibitor. Selective, competitive DNA polymerase inhibitor.
- CAS Number: 74310-84-2
- Purity: > 95%
Soluble in DMSO (10 mg/ml), ethanol (1 mg/ml), methanol (1 mg/ml) or water (1 mg/ml).
- Form / State: Solid
- Source: Trichoderma sp.
Overview
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Product name
Heptelidic acid (Koningic acid), GAPDH inhibitor -
Description
Potent, selective, irreversible GAPDH inhibitor. Selective, competitive DNA polymerase inhibitor. -
Purity
> 95% -
CAS Number
74310-84-2 -
Chemical structure
Properties
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Chemical name
(5aS,6R,9S,9aS)-1-Oxo-6-propan-2-ylspiro[3,5a,6,7,8,9a-hexahydro-2-benzoxepine-9,2'-oxirane]-4-carboxylic acid
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Molecular weight
280.32 -
Molecular formula
C15H20O5 -
PubChem identifier
10945834 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO (10 mg/ml), ethanol (1 mg/ml), methanol (1 mg/ml) or water (1 mg/ml).
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Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC(C)[C@H]1CC[C@@]2(CO2)[C@@H]3[C@@H]1C=C(COC3=O)C(=O)O -
Source
Trichoderma sp.
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Research areas
Images
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Chemical Structure - Heptelidic acid (Koningic acid), GAPDH inhibitor (ab144269)2D chemical structure image of ab144269, Heptelidic acid (Koningic acid), GAPDH inhibitor
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (2)
ab144269 has been referenced in 2 publications.
- Kondo H et al. Single-cell resolved imaging reveals intra-tumor heterogeneity in glycolysis, transitions between metabolic states, and their regulatory mechanisms. Cell Rep 34:108750 (2021). PubMed: 33596424
- Gaude E et al. NADH Shuttling Couples Cytosolic Reductive Carboxylation of Glutamine with Glycolysis in Cells with Mitochondrial Dysfunction. Mol Cell 69:581-593.e7 (2018). PubMed: 29452638