Ibotenic acid, excitotoxic agonist (ab120041)
Key features and details
- Excitotoxic agonist
- CAS Number: 2552-55-8
- Soluble in water to 10 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Ibotenic acid, excitotoxic agonist -
Description
Excitotoxic agonist -
Biological description
Neuroexcitatory amino acid originally isolated from Amanita species. Neurotoxin often used to model cognitive dysfunctions. NMDA and metabotropic receptor agonist.
Also available in simple stock solutions (ab146670) - add 1 ml of water to get an exact, ready-to-use concentration. -
CAS Number
2552-55-8 -
Chemical structure
Properties
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Chemical name
2-Amino-2-(3-hydroxyisoxazol-5-yl)acetic acid -
Molecular weight
158.11 -
Molecular formula
C5H6N2O4 -
PubChem identifier
1233 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 10 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
NC(C(=O)O)c1cc(O)no1 -
Source
Synthetic
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Research areas
Images
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Chemical Structure - Ibotenic acid, excitotoxic agonist (ab120041)2D chemical structure image of ab120041, Ibotenic acid, excitotoxic agonist
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Functional Studies - Ibotenic acid, excitotoxic agonist (ab120041)Image from Masini CV et al., Brain Res. 2013;1443:18-26. Fig 1.; doi: 10.1016/j.brainres.2012.01.002 with permission from Elsevier.Representative examples of NeuN immunohistochemistry of a complete auditory cortex lesion or sham-operated control section. Rats were anesthetized with halothane and placed in a Kopf stereotaxic apparatus. The skin overlying the skull was disinfected, an incision made, and small burr holes drilled through the skull bone to allow penetration of the injector (Hamilton 1 µl syringe). Bilateral excitotoxic lesions (two per side) were produced by injections of 0.25 µl ibotenic acid (10 µg/µl in 0.1 M sodium phosphate buffer, pH: 7.4; ab120041). The rate of infusion was 0.05 µl/min. The injector was lowered in the brain and left in place 3 min before and 5 min after each injection.
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (13)
ab120041 has been referenced in 13 publications.
- Guitchounts G et al. Encoding of 3D Head Orienting Movements in the Primary Visual Cortex. Neuron 108:512-525.e4 (2020). PubMed: 32783881
- Tanaka YH et al. Thalamocortical Axonal Activity in Motor Cortex Exhibits Layer-Specific Dynamics during Motor Learning. Neuron 100:244-258.e12 (2018). PubMed: 30174116
- Guirado R et al. Evidence for Competition for Target Innervation in the Medial Prefrontal Cortex. Cereb Cortex 26:1287-94 (2016). PubMed: 26637448
- Murray JE et al. Basolateral and central amygdala differentially recruit and maintain dorsolateral striatum-dependent cocaine-seeking habits. Nat Commun 6:10088 (2015). PubMed: 26657320
- Poliwoda A et al. Determination of muscimol and ibotenic acid in mushrooms of Amanitaceae by capillary electrophoresis. Electrophoresis 35:2593-9 (2014). PubMed: 24981810