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    products/biochemicals/imipramine-hydrochloride-tricyclic-antidepressant-ab141046.pdf

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Neuroscience Neurotransmitter Biogenic Amines Serotonin / 5HT
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Imipramine hydrochloride, Tricyclic antidepressant (ab141046)

  • Datasheet
  • SDS
  • COA
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Chemical Structure - Imipramine hydrochloride, Tricyclic antidepressant (ab141046)

    Key features and details

    • Tricyclic antidepressant
    • CAS Number: 113-52-0
    • Purity: > 98%
    • Soluble in water to 100 mM
    • Form / State: Solid
    • Source: Synthetic

    Overview

    • Product name

      Imipramine hydrochloride, Tricyclic antidepressant
    • Description

      Tricyclic antidepressant
    • Alternative names

      • Imipramine
    • Biological description

      Tricyclic antidepressant with various pharmacological activities. Inhibits reuptake inhibitors (Ki values are 19, 98 and >1000 nM for SERT, NET and DAT, respectively). Muscarinic receptor inhibitor (IC50 = 0.13 μM for M2). Serotonin receptor inhibitor (Ki values are 94 and 160 nM for 5-HT2A and 5-HT2C, respectively). Crosses the blood-brain barrier.

    • Purity

      > 98%
    • CAS Number

      113-52-0
    • Chemical structure

      Chemical Structure

    Properties

    • Chemical name

      10,11-Dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine hydrochloride
    • Molecular weight

      316.87
    • Molecular formula

      C19H24N2.HCl
    • PubChem identifier

      8228
    • Storage instructions

      Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
    • Solubility overview

      Soluble in water to 100 mM
    • Handling

      Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

      Refer to SDS for further information.

      Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

    • SMILES

      Cl.CN(C)CCCN2c3ccccc3CCc1ccccc12
    • Source

      Synthetic

    • Research areas

      • Neuroscience
      • Neurotransmitter
      • Biogenic Amines
      • Serotonin / 5HT
      • Neuroscience
      • Neurotransmitter
      • Transporters
      • Other
      • Neuroscience
      • Neurotransmission
      • Receptors / Channels
      • Potassium Channels
      • Neuroscience
      • Neurotransmission
      • Receptors / Channels
      • Sodium Channels
      • Neuroscience
      • Neurotransmission
      • Receptors / Channels
      • GPCR
      • Adrenergic Receptors
      • Neuroscience
      • Neurotransmission
      • Receptors / Channels
      • GPCR
      • Serotonin Receptors
      • Neuroscience
      • Neurotransmission
      • Receptors / Channels
      • GPCR
      • Muscarinic Receptors
      • Immunology
      • Innate Immunity
      • Macrophage / Inflamm.
      • Epigenetics and Nuclear Signaling
      • Transcription
      • Domain Families
      • Zinc Finger
      • Epigenetics and Nuclear Signaling
      • Transcription
      • Domain Families
      • HLH / Leucine Zipper
      • Leucine Zipper
      • Neuroscience
      • Neurology process
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      • Signal Transduction
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      • Thyroid axis
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      • Corticoid
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      • Retinoic & Retinoid
      • Epigenetics and Nuclear Signaling
      • Nuclear Signaling Pathways
      • Nuclear Receptors
      • Testosterone
      • Epigenetics and Nuclear Signaling
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      • Transcription
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      • Oncoproteins/suppressors
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      • Cardiovascular
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      • Blood Pressure regulation
      • Cardiovascular
      • Heart
      • Cardiac arrhythmias
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      • Cardiovascular
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      • Product Range
      • Just Add Water
      • Biochemicals
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      • Adrenoceptors
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      • Serotonin
      • Transporters
      • Biochemicals
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      • Receptors & Transporters
      • Muscarinic
      • Non-selective
      • Antagonists
      • Biochemicals
      • Pharmacology
      • Receptors & Transporters
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      • Hypoxia
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      • Research Area
      • Alzheimer's Disease
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      • Non-selective
      • Antagonists
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      • Research Area
      • Depression
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      • Transporters
      • Biochemicals
      • Research Area
      • Heart disease
      • Adrenoceptors
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      • Biochemicals
      • Research Area
      • Hypertension
      • Adrenoceptors
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      • Biochemicals
      • Research Area
      • Obesity
      • Muscarinic
      • Non-selective
      • Antagonists
      • Biochemicals
      • Research Area
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      • Research Area
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      • Research Area
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      • Research Area
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      • Biochemicals
      • Research Area
      • Respiratory disease
      • Muscarinic
      • Non-selective
      • Antagonists
      • Biochemicals
      • Research Area
      • Schizophrenia
      • Adrenoceptors
      • Transporters
      • Biochemicals
      • Research Area
      • Schizophrenia
      • Muscarinic
      • Non-selective
      • Antagonists
      • Biochemicals
      • Research Area
      • Schizophrenia
      • Serotonin
      • Transporters
      • Biochemicals
      • Research Area
      • Stress / Anxiety
      • Adrenoceptors
      • Transporters
      • Biochemicals
      • Research Area
      • Stress / Anxiety
      • Serotonin
      • Transporters

    Images

    • Chemical Structure - Imipramine hydrochloride, Tricyclic antidepressant (ab141046)
      Chemical Structure - Imipramine hydrochloride, Tricyclic antidepressant (ab141046)
      2D chemical structure image of ab141046, Imipramine hydrochloride, Tricyclic antidepressant

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • SDS download

    • Datasheet download

      Download
    • COA

    References (2)

    Publishing research using ab141046? Please let us know so that we can cite the reference in this datasheet.

    ab141046 has been referenced in 2 publications.

    • Nollet M Models of Depression: Unpredictable Chronic Mild Stress in Mice. Curr Protoc 1:e208 (2021). PubMed: 34406704
    • Yue X  et al. TMC Proteins Modulate Egg Laying and Membrane Excitability through a Background Leak Conductance in C. elegans. Neuron 97:571-585.e5 (2018). PubMed: 29395910

    Customer reviews and Q&As

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