Imipramine hydrochloride, Tricyclic antidepressant (ab141046)
Key features and details
- Tricyclic antidepressant
- CAS Number: 113-52-0
- Purity: > 98%
- Soluble in water to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Imipramine hydrochloride, Tricyclic antidepressant -
Description
Tricyclic antidepressant -
Alternative names
- Imipramine
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Biological description
Tricyclic antidepressant with various pharmacological activities. Inhibits reuptake inhibitors (Ki values are 19, 98 and >1000 nM for SERT, NET and DAT, respectively). Muscarinic receptor inhibitor (IC50 = 0.13 μM for M2). Serotonin receptor inhibitor (Ki values are 94 and 160 nM for 5-HT2A and 5-HT2C, respectively). Crosses the blood-brain barrier.
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Purity
> 98% -
CAS Number
113-52-0 -
Chemical structure
Properties
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Chemical name
10,11-Dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine hydrochloride -
Molecular weight
316.87 -
Molecular formula
C19H24N2.HCl -
PubChem identifier
8228 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Cl.CN(C)CCCN2c3ccccc3CCc1ccccc12 -
Source
Synthetic
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Research areas
- Signal Transduction
- Signaling Pathway
- Nuclear Signaling
- Nuclear Hormone Receptors
- Retinoic & Retinoid
- Epigenetics and Nuclear Signaling
- Nuclear Signaling Pathways
- Nuclear Receptors
- Orphan Nuclear Receptors
Images
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Chemical Structure - Imipramine hydrochloride, Tricyclic antidepressant (ab141046)2D chemical structure image of ab141046, Imipramine hydrochloride, Tricyclic antidepressant
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (2)
ab141046 has been referenced in 2 publications.
- Nollet M Models of Depression: Unpredictable Chronic Mild Stress in Mice. Curr Protoc 1:e208 (2021). PubMed: 34406704
- Yue X et al. TMC Proteins Modulate Egg Laying and Membrane Excitability through a Background Leak Conductance in C. elegans. Neuron 97:571-585.e5 (2018). PubMed: 29395910