IPA 3, Group I, p21-activated kinase (PAK) inhibitor (ab141014)
Key features and details
- Group I, p21-activated kinase (PAK) inhibitor
- CAS Number: 42521-82-4
- Purity: > 97%
- Soluble in DMSO to 100 mM and in ethanol to 25 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
IPA 3, Group I, p21-activated kinase (PAK) inhibitor -
Description
Group I, p21-activated kinase (PAK) inhibitor -
Biological description
Group I, p21-activated kinase (PAK) inhibitor (IC50 = 2.5 μM). Non-ATP competitive, allosteric inhibition in vivo. Selectivity over >200 other kinases.
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Purity
> 97% -
CAS Number
42521-82-4 -
Chemical structure
Properties
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Chemical name
1,1'-Dithiobis-2-naphthalenol -
Molecular weight
350.45 -
Molecular formula
C20H14O2S2 -
PubChem identifier
521106 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM and in ethanol to 25 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Oc4ccc1ccccc1c4SSc3c(O)ccc2ccccc23 -
Source
Synthetic
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Research areas
- Signal Transduction
- Signaling Pathway
- Nuclear Signaling
- Nuclear Hormone Receptors
- Vitamin D Receptor
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Nucleotide metabolism
- Molecular processes
- Mitochondrial transcription
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Energy transfer pathways
- Energy Metabolism
Images
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Chemical Structure - IPA 3, Group I, p21-activated kinase (PAK) inhibitor (ab141014)2D chemical structure image of ab141014, IPA 3, Group I, p21-activated kinase (PAK) inhibitor
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (1)
ab141014 has been referenced in 1 publication.
- Liu JS et al. ß-elemene enhances the radiosensitivity of gastric cancer cells by inhibiting Pak1 activation. World J Gastroenterol 21:9945-56 (2015). PubMed: 26379399