JC-1, Mitochondrial membrane potential dye (ab141387)
Key features and details
- Mitochondrial membrane-potential dye
- CAS Number: 3520-43-2
- Purity: > 98%
- Soluble in DMSO to 25 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
JC-1, Mitochondrial membrane potential dye -
Description
Mitochondrial membrane-potential dye -
Purity
> 98% -
CAS Number
3520-43-2 -
Chemical structure
Properties
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Excitation
519nm -
Emission
590nm -
Chemical name
5,6-Dichloro-2-[(E)-3-(5,6-dichloro-1,3-diethyl-1,3-dihydro-2H-benzimidazol-2-ylidene)-1-prop-1-enyl]-1,3-diethyl-1H-benzimidazolium iodide -
Molecular weight
652.23 -
Molecular formula
C25H27Cl4IN4 -
PubChem identifier
5492929 -
Storage instructions
Shipped at 4°C. Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 25 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CCN1C2=CC(=C(C=C2[N+](=C1C=CC=C3N(C4=CC(=C(C=C4N3CC)Cl)Cl)CC)CC)Cl)Cl.[I-] -
Source
Synthetic
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Research areas
Images
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Chemical Structure - JC-1, Mitochondrial membrane potential dye (ab141387)2D chemical structure image of ab141387, JC-1, Mitochondrial membrane potential dye
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (17)
ab141387 has been referenced in 17 publications.
- Ding J et al. HADHA alleviates hepatic steatosis and oxidative stress in NAFLD via inactivation of the MKK3/MAPK pathway. Mol Biol Rep 50:961-970 (2023). PubMed: 36376538
- Dong X et al. Inhibition of miR-421 Preserves Mitochondrial Function and Protects against Parkinson's Disease Pathogenesis via Pink1/Parkin-Dependent Mitophagy. Dis Markers 2022:5186252 (2022). PubMed: 35664430
- Rodríguez-Nuevo A et al. Oocytes maintain ROS-free mitochondrial metabolism by suppressing complex I. Nature 607:756-761 (2022). PubMed: 35859172
- Chen J et al. Inhibition of Autophagy Prevents Panax Notoginseng Saponins (PNS) Protection on Cardiac Myocytes Against Endoplasmic Reticulum (ER) Stress-Induced Mitochondrial Injury, Ca2+ Homeostasis and Associated Apoptosis. Front Pharmacol 12:620812 (2021). PubMed: 33762943
- Britti E et al. Calcitriol increases frataxin levels and restores mitochondrial function in cell models of Friedreich Ataxia. Biochem J 478:1-20 (2021). PubMed: 33305808