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    products/biochemicals/kainic-acid-prototypic-kainate-receptor-agonist-ab120100.pdf

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Kainic acid, prototypic kainate receptor agonist (ab120100)

  • Datasheet
  • COA
Submit a review Q&A (1)References (58)

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Key features and details

  • Prototypic kainate receptor agonist
  • CAS Number: 487-79-6
  • Soluble in water to 25 mM
  • Form / State: Solid
  • Source: Digenea simplex

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Overview

  • Product name

    Kainic acid, prototypic kainate receptor agonist
  • Description

    Prototypic kainate receptor agonist
  • Alternative names

    • Kainate
  • Biological description

    Prototypic agonist at the kainate class of ionotropic glutamate receptors. Potent excitant and neurotoxin, used to model epilepsy and neurodegenerative states. Also available in Kit(s): Ionotropic agonists (ab120323).

    Also available in simple stock solutions (ab144490) - add 1 ml of water to get an exact, ready-to-use concentration.

  • CAS Number

    487-79-6
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (2S,3S,4S)-3-(Carboxymethyl)-4-(prop-1-en-2-yl)pyrrolidine-2-carboxylic acid
  • Molecular weight

    213.23
  • Molecular formula

    C10H15NO4
  • PubChem identifier

    10255
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 25 mM
  • Handling

    This product is supplied in one (or more) pack size which is freeze dried. Therefore the contents may not be readily visible, as they can coat the bottom or walls of the vial. Please see our FAQs and information page for more details on handling.

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(=C)[C@H]1CN[C@@H]([C@H]1CC(=O)O)C(=O)O
  • Source

    Digenea simplex

  • Research areas

    • Neuroscience
    • Neurotransmitter
    • Amino Acids
    • Glutamate
    • Neuroscience
    • Neurotransmission
    • Receptors / Channels
    • GPCR
    • Glutamate Receptors
    • Neuroscience
    • Neurotransmission
    • Receptors / Channels
    • Ligand-Gated Ion Channels
    • AMPA / Kainate
    • Biochemicals
    • Product Range
    • Just Add Water
    • Biochemicals
    • Chemical Type
    • Amino Acid
    • Biochemicals
    • Chemical Type
    • Biochemicals
    • Biochemicals
    • Pharmacology
    • Receptors & Transporters
    • Glutamate
    • AMPA & Kainate
    • Biochemicals
    • Pharmacology
    • Receptors & Transporters
    • Glutamate
    • AMPA & Kainate
    • Agonists
    • Biochemicals
    • Research Area
    • Addiction
    • Glutamate
    • AMPA & Kainate
    • Biochemicals
    • Research Area
    • Addiction
    • Glutamate
    • AMPA & Kainate
    • Agonists
    • Biochemicals
    • Research Area
    • Alzheimer's Disease
    • Glutamate
    • AMPA & Kainate
    • Biochemicals
    • Research Area
    • Alzheimer's Disease
    • Glutamate
    • AMPA & Kainate
    • Agonists
    • Biochemicals
    • Research Area
    • Depression
    • Glutamate
    • AMPA & Kainate
    • Biochemicals
    • Research Area
    • Depression
    • Glutamate
    • AMPA & Kainate
    • Agonists
    • Biochemicals
    • Research Area
    • Pain & inflammation
    • Glutamate
    • AMPA & Kainate
    • Biochemicals
    • Research Area
    • Pain & inflammation
    • Glutamate
    • AMPA & Kainate
    • Agonists
    • Biochemicals
    • Research Area
    • Parkinson's Disease
    • Glutamate
    • AMPA & Kainate
    • Biochemicals
    • Research Area
    • Parkinson's Disease
    • Glutamate
    • AMPA & Kainate
    • Agonists
    • Biochemicals
    • Research Area
    • Schizophrenia
    • Glutamate
    • AMPA & Kainate
    • Biochemicals
    • Research Area
    • Schizophrenia
    • Glutamate
    • AMPA & Kainate
    • Agonists
    • Biochemicals
    • Research Area
    • Stroke
    • Glutamate
    • AMPA & Kainate
    • Biochemicals
    • Research Area
    • Stroke
    • Glutamate
    • AMPA & Kainate
    • Agonists
    • Neuroscience
    • Processes

Applications

The Abpromise guarantee

Our Abpromise guarantee covers the use of ab120100 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Functional Studies
Use at an assay dependent concentration.
Notes
Functional Studies
Use at an assay dependent concentration.

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

Datasheets and documents

  • Datasheet download

    Download
  • COA

References (58)

Publishing research using ab120100? Please let us know so that we can cite the reference in this datasheet.

ab120100 has been referenced in 58 publications.

  • Wu D  et al. Nanoengineered on-demand drug delivery system improves efficacy of pharmacotherapy for epilepsy. Sci Adv 8:eabm3381 (2022). PubMed: 35020438
  • Chen KD  et al. Augmented seizure susceptibility and hippocampal epileptogenesis in a translational mouse model of febrile status epilepticus. Epilepsia 62:647-658 (2021). PubMed: 33475157
  • Wu K  et al. Activity- and sleep-dependent regulation of tonic inhibition by Shisa7. Cell Rep 34:108899 (2021). PubMed: 33761345
  • Nevoux J  et al. An antibody to RGMa promotes regeneration of cochlear synapses after noise exposure. Sci Rep 11:2937 (2021). PubMed: 33536466
  • Tang Y  et al. Structure-based discovery of CZL80, a caspase-1 inhibitor with therapeutic potential for febrile seizures and later enhanced epileptogenic susceptibility. Br J Pharmacol 177:3519-3534 (2020). PubMed: 32346861
View all Publications for this product

Customer reviews and Q&As

Show All Reviews Q&A
Submit a review Submit a question

Question

Is this antibody kainic acid monohydrate?

Read More

Abcam community

Verified customer

Asked on Jul 12 2013

Answer

The water content varies between batches but the batch molecular formula appears on the vial label and also in the CoA for the batch.
Some batches are the monohydrate (CoA will state H20), some are anhydrous (CoA would not mention H20) and some are in between (CoA will state a fraction of water e.g. 0.75H20).
The three batches that we have in stock (APN11387-6-3, APN13056-1-1 and APN13058-1-1) vary in their formulation.
APN11387-6-3 – in between
APN13056-1-1 – monohydrate
APN13058-1-1 – anhydrous

Read More

Kevin Hanson

Abcam Scientific Support

Answered on Jul 12 2013

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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