KB-R7943, NCX inhibitor (ab120284)
Key features and details
- NCX inhibitor. TRPC blocker.
- CAS Number: 182004-65-5
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
-
Product name
KB-R7943, NCX inhibitor -
Description
NCX inhibitor. TRPC blocker. -
Biological description
Potent, selective inhibitor of the reverse mode of the Na+/Ca2+ exchanger (IC50 = ~0.32 μM in guinea pig ventricular cells). Also potent blocker of TRPC channels (IC50 values are 0.46, 0.71 and 1.38 μM at TRPC3, TRPC6 and TRPC5, respectively).
-
CAS Number
182004-65-5 -
Chemical structure
Properties
-
Chemical name
2-[4-[(4-nitrophenyl)methoxy]phenyl]ethyl ester carbamimidothioic acid methanesulfonate -
Molecular weight
427.49 -
Molecular formula
C16H17N3O3S.CH3SO3H -
PubChem identifier
9823846 -
Storage instructions
Store at Room Temperature. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
-
SMILES
CS(=O)(=O)O.[O-][N+](=O)c2ccc(COc1ccc(cc1)CCSC(=N)N)cc2 -
Source
Synthetic
-
Research areas
Images
-
Chemical Structure - KB-R7943, NCX inhibitor (ab120284)2D chemical structure image of ab120284, KB-R7943, NCX inhibitor
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (4)
ab120284 has been referenced in 4 publications.
- Wong RW et al. An activator of G protein-coupled receptor and MEK1/2-ERK1/2 signaling inhibits HIV-1 replication by altering viral RNA processing. PLoS Pathog 16:e1008307 (2020). PubMed: 32069328
- Wong RW et al. Cardiac glycoside/aglycones inhibit HIV-1 gene expression by a mechanism requiring MEK1/2-ERK1/2 signaling. Sci Rep 8:850 (2018). PubMed: 29339801
- Di Giuro CML et al. Na +/Ca2+ exchangers and Orai channels jointly refill endoplasmic reticulum (ER) Ca2+ via ER nanojunctions in vascular endothelial cells. Pflugers Arch 469:1287-1299 (2017). PubMed: 28497275
- Sherkhane P & Kapfhammer JP Chronic pharmacological blockade of the Na(+) /Ca(2+) exchanger modulates the growth and development of the Purkinje cell dendritic arbor in mouse cerebellar slice cultures. Eur J Neurosci N/A:N/A (2017). PubMed: 28715135