Ketoconazole, cytochrome P450 inhibitor (ab120620)
Key features and details
- Potent cytochrome P450 inhibitor. Antifungal agent.
- CAS Number: 65277-42-1
- Purity: > 99%
- Soluble in DMSO to 75 mM and in ethanol to 50 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Ketoconazole, cytochrome P450 inhibitor -
Description
Potent cytochrome P450 inhibitor. Antifungal agent. -
Biological description
Potent cytochrome P450 inhibitor (Ki values are 26.7 and 109 nM at CYP3A4 and CYP3A5, respectively). Antifungal agent. Additionally, shows activity at human androgen receptors.
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Purity
> 99% -
CAS Number
65277-42-1 -
Chemical structure
Properties
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Chemical name
(±)-cis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine -
Molecular weight
531.44 -
Molecular formula
C26H28Cl2N4O4 -
PubChem identifier
456201 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 75 mM and in ethanol to 50 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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Source
Synthetic
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Research areas
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Nucleotide metabolism
- Molecular processes
- Mitochondrial transcription
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Lipid metabolism
Images
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Chemical Structure - Ketoconazole, cytochrome P450 inhibitor (ab120620)2D chemical structure image of ab120620, Ketoconazole, cytochrome P450 inhibitor
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (1)
ab120620 has been referenced in 1 publication.
- Islam M et al. Microfluidic cell sorting by stiffness to examine heterogenic responses of cancer cells to chemotherapy. Cell Death Dis 9:239 (2018). PubMed: 29445159