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    products/biochemicals/kn-93-water-soluble-camk-ii-inhibitor-ab120980.pdf

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Neuroscience Neurotransmission Calcium Signaling Calmodulin / CaMK
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KN-93 (water soluble), CaMK II inhibitor (ab120980)

  • Datasheet
  • SDS
  • COA
Submit a review Q&A (1)References (3)

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Chemical Structure - KN-93 (water soluble), CaMK II inhibitor (ab120980)
  • Immunocytochemistry/ Immunofluorescence - KN-93 (water soluble), CaMK II inhibitor (ab120980)

Key features and details

  • Potent, specific CaMK II inhibitor
  • CAS Number: 1188890-41-6
  • Purity: > 99%
  • Soluble in water to 100 mM and in DMSO to 100 mM
  • Form / State: Solid
  • Source: Synthetic

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Overview

  • Product name

    KN-93 (water soluble), CaMK II inhibitor
  • Description

    Potent, specific CaMK II inhibitor
  • Purity

    > 99%
  • CAS Number

    1188890-41-6
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    N-[2-[[[(2E)-3-(4-Chlorophenyl)-2-propen-1-yl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide phosphate
  • Molecular weight

    599.03
  • Molecular formula

    C26H29ClN2O4S.H3PO4
  • PubChem identifier

    16760530
  • Storage instructions

    Store at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions.
  • Solubility overview

    Soluble in water to 100 mM and in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    Clc3ccc(/C=C/CN(C)Cc2ccccc2N(CCO)S(=O)(=O)c1ccc(OC)cc1)cc3.O=P(O)(O)O
  • Source

    Synthetic

  • Research areas

    • Neuroscience
    • Neurotransmission
    • Calcium Signaling
    • Calmodulin / CaMK
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Applications

The Abpromise guarantee

Our Abpromise guarantee covers the use of ab120980 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Functional Studies
Use at an assay dependent concentration.
Notes
Functional Studies
Use at an assay dependent concentration.

Images

  • Chemical Structure - KN-93 (water soluble), CaMK II inhibitor (ab120980)
    Chemical Structure - KN-93 (water soluble), CaMK II inhibitor (ab120980)
    2D chemical structure image of ab120980, KN-93 (water soluble), CaMK II inhibitor
  • Immunocytochemistry/ Immunofluorescence - KN-93 (water soluble), CaMK II inhibitor (ab120980)
    Immunocytochemistry/ Immunofluorescence - KN-93 (water soluble), CaMK II inhibitor (ab120980)
    ab40754 staining cyclin D1 in MCF7 cells treated with KN-93 (water soluble) (ab120980), by ICC/IF. Decrease in cyclin D1 expression correlates with increased concentration of KN-93 (water soluble), as described in literature.
    The cells were incubated at 37°C for 24 hours in media containing different concentrations of ab120980 (KN-93 (water soluble)) in DMSO, fixed with 100% methanol for 5 minutes at -20°C and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab40754 (1/100 dilution) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

Datasheets and documents

  • SDS download

  • Datasheet download

    Download
  • COA

References (3)

Publishing research using ab120980? Please let us know so that we can cite the reference in this datasheet.

ab120980 has been referenced in 3 publications.

  • Yong XLH  et al. Regulation of NMDA receptor trafficking and gating by activity-dependent CaMKIIa phosphorylation of the GluN2A subunit. Cell Rep 36:109338 (2021). PubMed: 34233182
  • Kaiser TS  et al. The genomic basis of circadian and circalunar timing adaptations in a midge. Nature 540:69-73 (2016). PubMed: 27871090
  • Teo CS & Chu JJ Cellular vimentin regulates construction of dengue virus replication complexes through interaction with NS4A protein. J Virol 88:1897-913 (2014). PubMed: 24284321

Customer reviews and Q&As

Show All Reviews Q&A
Submit a review Submit a question

Question

Customer has kindly contacting us regarding the solubility of this product in H2O. While the producrt datasheet says "KN-93 (water soluble)", only solubility in DMSO is listed.

Read More

Abcam community

Verified customer

Asked on Apr 05 2013

Answer

The lab have completed our analysis and can confirm that this product is soluble in water to 100 mM with prolonged shaking.

Read More

Abcam Scientific Support

Answered on Apr 05 2013

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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