Key features and details
- Selective Hsp27 inhibitor. Microtubule inhibitor.
- CAS Number: 129414-88-6
- Purity: > 98%
- Soluble in DMSO to 25 mM
- Form / State: Solid
- Source: Synthetic
Product nameKRIBB3 (5-(5-Ethyl-2-hydroxy-4-methoxyphenyl)-4-(4-methoxyphenyl)isoxazole), Hsp27 inhibitor
DescriptionSelective Hsp27 inhibitor. Microtubule inhibitor.
Biological descriptionSelective Hsp27 inhibitor. Microtubule inhibitor. Inhibits PKC-dependent Hsp27-phosphorylation. Induces mitotic arrest and apoptosis in cancer cells. Shows antitumor effects in vivo.
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 25 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab146011 has not yet been referenced specifically in any publications.