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    kynurenic-acid-endogenous-ionotropic--nicotinic-antagonist-ab120064.pdf

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Kynurenic acid, endogenous ionotropic / nicotinic antagonist (ab120064)

  • Datasheet
  • SDS
  • COA
Submit a review Q&A (1)References (27)

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Chemical Structure - Kynurenic acid, endogenous ionotropic / nicotinic antagonist (ab120064)
  • Functional Studies - Kynurenic acid, endogenous ionotropic / nicotinic antagonist (ab120064)

Key features and details

  • Endogenous ionotropic / nicotinic antagonist
  • CAS Number: 492-27-3
  • Soluble in 1 eq. NaOH to 100 mM and in DMSO to 50 mM
  • Form / State: Solid
  • Source: Synthetic

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Overview

  • Product name

    Kynurenic acid, endogenous ionotropic / nicotinic antagonist
  • Description

    Endogenous ionotropic / nicotinic antagonist
  • Biological description

    Endogenous antagonist at ionotropic, glycine β and α7 nicotinic receptors. Neuroprotective in vivo. Water-soluble form available - please see Kynurenic acid sodium salt (ab120256)

  • CAS Number

    492-27-3
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    4-Hydroxyquinoline-2-carboxylic acid
  • Molecular weight

    189.17
  • Molecular formula

    C10H7NO3
  • PubChem identifier

    3845
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in 1 eq. NaOH to 100 mM and in DMSO to 50 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    O=C(O)c1cc(O)c2ccccc2n1
  • Source

    Synthetic

  • Research areas

    • Neuroscience
    • Neurotransmitter
    • Amino Acids
    • Glutamate
    • Neuroscience
    • Neurotransmission
    • Receptors / Channels
    • GPCR
    • Glutamate Receptors
    • Neuroscience
    • Neurotransmission
    • Receptors / Channels
    • GPCR
    • More GPCR
    • Neuroscience
    • Neurotransmission
    • Receptors / Channels
    • Ligand-Gated Ion Channels
    • NMDA Receptors
    • Neuroscience
    • Neurotransmission
    • Receptors / Channels
    • Ligand-Gated Ion Channels
    • nAch Receptors
    • Epigenetics and Nuclear Signaling
    • Transcription
    • Domain Families
    • HLH / Leucine Zipper
    • Helix-Turn-Helix
    • Signal Transduction
    • Signaling Pathway
    • G Protein Signaling
    • GPCR
    • Neuroscience
    • Sensory System
    • Somatosensory system
    • Nociception
    • Neuroscience
    • Neurology process
    • Neurodegenerative disease
    • Other
    • Biochemicals
    • Chemical Type
    • Biochemicals
    • Biochemicals
    • Pharmacology
    • Receptors & Transporters
    • Nicotinic
    • α7
    • Biochemicals
    • Pharmacology
    • Receptors & Transporters
    • Glutamate
    • Broad spectrum / non-selective
    • Antagonists
    • Biochemicals
    • Pharmacology
    • Receptors & Transporters
    • Nicotinic
    • α7
    • Antagonists
    • Biochemicals
    • Research Area
    • Addiction
    • Glutamate
    • Broad spectrum / non-selective
    • Antagonists
    • Biochemicals
    • Research Area
    • Addiction
    • Nicotinic
    • α7
    • Biochemicals
    • Research Area
    • Addiction
    • Nicotinic
    • α7
    • Antagonists
    • Biochemicals
    • Research Area
    • Alzheimer's Disease
    • Glutamate
    • Broad spectrum / non-selective
    • Antagonists
    • Biochemicals
    • Research Area
    • Alzheimer's Disease
    • Nicotinic
    • α7
    • Biochemicals
    • Research Area
    • Alzheimer's Disease
    • Nicotinic
    • α7
    • Antagonists
    • Biochemicals
    • Research Area
    • Depression
    • Glutamate
    • Broad spectrum / non-selective
    • Antagonists
    • Biochemicals
    • Research Area
    • Pain & inflammation
    • Glutamate
    • Broad spectrum / non-selective
    • Antagonists
    • Biochemicals
    • Research Area
    • Parkinson's Disease
    • Glutamate
    • Broad spectrum / non-selective
    • Antagonists
    • Biochemicals
    • Research Area
    • Parkinson's Disease
    • Nicotinic
    • α7
    • Biochemicals
    • Research Area
    • Parkinson's Disease
    • Nicotinic
    • α7
    • Antagonists
    • Biochemicals
    • Research Area
    • Schizophrenia
    • Glutamate
    • Broad spectrum / non-selective
    • Antagonists
    • Biochemicals
    • Research Area
    • Schizophrenia
    • Nicotinic
    • α7
    • Biochemicals
    • Research Area
    • Schizophrenia
    • Nicotinic
    • α7
    • Antagonists
    • Biochemicals
    • Research Area
    • Stroke
    • Glutamate
    • Broad spectrum / non-selective
    • Antagonists

Images

  • Chemical Structure - Kynurenic acid, endogenous ionotropic / nicotinic antagonist (ab120064)
    Chemical Structure - Kynurenic acid, endogenous ionotropic / nicotinic antagonist (ab120064)
    2D chemical structure image of ab120064, Kynurenic acid, endogenous ionotropic / nicotinic antagonist
  • Functional Studies - Kynurenic acid, endogenous ionotropic / nicotinic antagonist (ab120064)
    Functional Studies - Kynurenic acid, endogenous ionotropic / nicotinic antagonist (ab120064)Image from Rudolph S et al., Neuron. 2011;70(5):991-1004. Fig 3.; doi: 10.1016/j.neuron.2011.03.029 with permission from Elsevier.
    C1 and C2 - Inhibition of climbing fiber to Purkinje cell EPSCs in (control; black) by 1 mM Kynurenic acid (red, ab120064) or 100 nM NBQX (green, ab120045) recorded in 2.5 mM external Ca2+ at 0.05 Hz (C1) and 2 Hz (C2) stimulation frequency. D - Summary of inhibition of EPSCs by 1 mM Kynurenic acid (red, ab120064) and 100 nM NBQX (green, ab120045) in 2.5 mM external Ca2+.

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

Datasheets and documents

  • SDS download

  • Datasheet download

    Download
  • COA

References (27)

Publishing research using ab120064? Please let us know so that we can cite the reference in this datasheet.

ab120064 has been referenced in 27 publications.

  • Barnes JL  et al. Developmentally Transient CB1Rs on Cerebellar Afferents Suppress Afferent Input, Downstream Synaptic Excitation, and Signaling to Migrating Neurons. J Neurosci 40:6133-6145 (2020). PubMed: 32631938
  • Heubl M  et al. GABAA receptor dependent synaptic inhibition rapidly tunes KCC2 activity via the Cl--sensitive WNK1 kinase. Nat Commun 8:1776 (2017). PubMed: 29176664
  • Hiu T  et al. Enhanced phasic GABA inhibition during the repair phase of stroke: a novel therapeutic target. Brain 139:468-80 (2016). PubMed: 26685158
  • Zarnowska ED  et al. Etomidate blocks LTP and impairs learning but does not enhance tonic inhibition in mice carrying the N265M point mutation in the beta3 subunit of the GABA(A) receptor. Neuropharmacology 93:171-178 (2015). PubMed: 25680234
  • Shin JH  et al. Muscarinic regulation of dopamine and glutamate transmission in the nucleus accumbens. Proc Natl Acad Sci U S A 112:8124-9 (2015). PubMed: 26080439
View all Publications for this product

Customer reviews and Q&As

Show All Reviews Q&A
Submit a review Submit a question

Question

What is the extinction coefficient of this compound?

Read More

Abcam community

Verified customer

Asked on Apr 10 2012

Answer

Thank you for your call yesterday and for your patience while I've been in touch with the lab regarding your enquiry.

We don't test the extinction coefficient in house, but my colleagues in the lab have found the following regarding the extinction coefficient of this compound:

Extinction coefficient: EmM = 9.8 (332 nm, pH 7)
7.92 (344 nm, pH 7)

I hope this will be useful, but please let me know if you have any further questions or if there is anything else that we can do for you, and I'll be happy to help.

Read More

Abcam Scientific Support

Answered on Apr 10 2012

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