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    products/biochemicals/kynurenic-acid-sodium-salt-endogenous-ionotropic--nicotinic-antagonist-ab120256.pdf

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Kynurenic acid sodium salt, Endogenous ionotropic / nicotinic antagonist (ab120256)

  • Datasheet
  • COA
Reviews (1) Submit a question References (10)

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Chemical Structure - Kynurenic acid sodium salt, Endogenous ionotropic / nicotinic antagonist (ab120256)

    Key features and details

    • Endogenous ionotropic / nicotinic antagonist; water soluble
    • CAS Number: 2439-02-3
    • Soluble in water to 100 mM

    • Form / State: Solid
    • Source: Synthetic

    Overview

    • Product name

      Kynurenic acid sodium salt, Endogenous ionotropic / nicotinic antagonist
    • Description

      Endogenous ionotropic / nicotinic antagonist; water soluble
    • Biological description

      Endogenous antagonist at ionotropic, glycine and α7 nicotinic receptors. Neuroprotective in vivo. Water soluble form.

      Also available in simple stock solutions (ab146693) - add 1 ml of water to get an exact, ready-to-use concentration.

    • CAS Number

      2439-02-3
    • Chemical structure

      Chemical Structure

    Properties

    • Chemical name

      4-Hydroxyquinoline-2-carboxylic acid sodium salt

    • Molecular weight

      211.15
    • Molecular formula

      C10H6NNaO3
    • PubChem identifier

      52974250
    • Storage instructions

      Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.
    • Solubility overview

      Soluble in water to 100 mM

    • Handling

      Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

      Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

    • SMILES

      O=C(O[Na])c1cc(O)c2ccccc2n1
    • Source

      Synthetic

    • Research areas

      • Neuroscience
      • Neurotransmitter
      • Amino Acids
      • Glutamate
      • Neuroscience
      • Neurotransmission
      • Receptors / Channels
      • GPCR
      • Glutamate Receptors
      • Neuroscience
      • Neurotransmission
      • Receptors / Channels
      • Ligand-Gated Ion Channels
      • nAch Receptors
      • Signal Transduction
      • Signaling Pathway
      • G Protein Signaling
      • GPCR
      • Biochemicals
      • Product Range
      • Just Add Water
      • Biochemicals
      • Chemical Type
      • Biochemicals
      • Biochemicals
      • Pharmacology
      • Receptors & Transporters
      • Nicotinic
      • α7
      • Biochemicals
      • Pharmacology
      • Receptors & Transporters
      • Glutamate
      • Broad spectrum / non-selective
      • Antagonists
      • Biochemicals
      • Pharmacology
      • Receptors & Transporters
      • Nicotinic
      • α7
      • Antagonists
      • Biochemicals
      • Research Area
      • Addiction
      • Glutamate
      • Broad spectrum / non-selective
      • Antagonists
      • Biochemicals
      • Research Area
      • Addiction
      • Nicotinic
      • α7
      • Biochemicals
      • Research Area
      • Addiction
      • Nicotinic
      • α7
      • Antagonists
      • Biochemicals
      • Research Area
      • Alzheimer's Disease
      • Glutamate
      • Broad spectrum / non-selective
      • Antagonists
      • Biochemicals
      • Research Area
      • Alzheimer's Disease
      • Nicotinic
      • α7
      • Biochemicals
      • Research Area
      • Alzheimer's Disease
      • Nicotinic
      • α7
      • Antagonists
      • Biochemicals
      • Research Area
      • Depression
      • Glutamate
      • Broad spectrum / non-selective
      • Antagonists
      • Biochemicals
      • Research Area
      • Pain & inflammation
      • Glutamate
      • Broad spectrum / non-selective
      • Antagonists
      • Biochemicals
      • Research Area
      • Parkinson's Disease
      • Glutamate
      • Broad spectrum / non-selective
      • Antagonists
      • Biochemicals
      • Research Area
      • Parkinson's Disease
      • Nicotinic
      • α7
      • Biochemicals
      • Research Area
      • Parkinson's Disease
      • Nicotinic
      • α7
      • Antagonists
      • Biochemicals
      • Research Area
      • Schizophrenia
      • Glutamate
      • Broad spectrum / non-selective
      • Antagonists
      • Biochemicals
      • Research Area
      • Schizophrenia
      • Nicotinic
      • α7
      • Biochemicals
      • Research Area
      • Schizophrenia
      • Nicotinic
      • α7
      • Antagonists
      • Biochemicals
      • Research Area
      • Stroke
      • Glutamate
      • Broad spectrum / non-selective
      • Antagonists
      • Neuroscience
      • Processes

    Associated products

    • Related Products

      • D-AP5, NMDA glutamate site antagonist (ab120003)
      • SR95531 (Gabazine), GABAA antagonist (ab120042)
      • NBQX disodium salt, AMPA / kainate antagonist (ab120046)
      • 4-Aminopyridine (4-AP), K+ channel blocker (ab120122)

    Images

    • Chemical Structure - Kynurenic acid sodium salt, Endogenous ionotropic / nicotinic antagonist (ab120256)
      Chemical Structure - Kynurenic acid sodium salt, Endogenous ionotropic / nicotinic antagonist (ab120256)
      2D chemical structure image of ab120256, Kynurenic acid sodium salt, Endogenous ionotropic / nicotinic antagonist

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet download

      Download
    • COA

    References (10)

    Publishing research using ab120256? Please let us know so that we can cite the reference in this datasheet.

    ab120256 has been referenced in 10 publications.

    • Naka A  et al. Complementary networks of cortical somatostatin interneurons enforce layer specific control. Elife 8:N/A (2019). PubMed: 30883329
    • Vaden JH  et al. The readily-releasable pool dynamically regulates multivesicular release. Elife 8:N/A (2019). PubMed: 31364987
    • Kim DW  et al. Multimodal Analysis of Cell Types in a Hypothalamic Node Controlling Social Behavior. Cell 179:713-728.e17 (2019). PubMed: 31626771
    • Bull FA  et al. Morphine activation of mu opioid receptors causes disinhibition of neurons in the ventral tegmental area mediated by ß-arrestin2 and c-Src. Sci Rep 7:9969 (2017). PubMed: 28855588
    • Turrini L  et al. Optical mapping of neuronal activity during seizures in zebrafish. Sci Rep 7:3025 (2017). PubMed: 28596596
    • Ferreira-Neto HC  et al. ATP stimulates rat hypothalamic sympathetic neurons by enhancing AMPA receptor-mediated currents. J Neurophysiol 114:159-69 (2015). PubMed: 25904713
    • Vashchinkina E  et al. Neurosteroid Agonist at GABAA receptor induces persistent neuroplasticity in VTA dopamine neurons. Neuropsychopharmacology 39:727-37 (2014). PubMed: 24077066
    • Bock R  et al. Strengthening the accumbal indirect pathway promotes resilience to compulsive cocaine use. Nat Neurosci 16:632-8 (2013). PubMed: 23542690
    • Mitra P & Brownstone RM An in vitro spinal cord slice preparation for recording from lumbar motoneurons of the adult mouse. J Neurophysiol 107:728-41 (2012). PubMed: 22031766
    • Brady JD  et al. Vesicular GABA release delays the onset of the Purkinje cell terminal depolarization without affecting tissue swelling in cerebellar slices during simulated ischemia. Neuroscience 168:108-17 (2010). PubMed: 20226232

    Customer reviews and Q&As

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    The reviewer received a reward from Abcam’s Loyalty Program in thanks for submitting this Abreview and for helping the scientific community make better-informed decisions.

    Madhura Athreya

    Verified customer

    Submitted Apr 01 2016

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