Kynurenic acid sodium salt, Endogenous ionotropic / nicotinic antagonist (ab120256)
Key features and details
- Endogenous ionotropic / nicotinic antagonist; water soluble
- CAS Number: 2439-02-3
Soluble in water to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Kynurenic acid sodium salt, Endogenous ionotropic / nicotinic antagonist -
Description
Endogenous ionotropic / nicotinic antagonist; water soluble -
Biological description
Endogenous antagonist at ionotropic, glycine and α7 nicotinic receptors. Neuroprotective in vivo. Water soluble form.
Also available in simple stock solutions (ab146693) - add 1 ml of water to get an exact, ready-to-use concentration. -
CAS Number
2439-02-3 -
Chemical structure
Properties
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Chemical name
4-Hydroxyquinoline-2-carboxylic acid sodium salt
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Molecular weight
211.15 -
Molecular formula
C10H6NNaO3 -
PubChem identifier
52974250 -
Storage instructions
Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 100 mM
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Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
O=C(O[Na])c1cc(O)c2ccccc2n1 -
Source
Synthetic
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Research areas
Associated products
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Related Products
Images
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Chemical Structure - Kynurenic acid sodium salt, Endogenous ionotropic / nicotinic antagonist (ab120256)2D chemical structure image of ab120256, Kynurenic acid sodium salt, Endogenous ionotropic / nicotinic antagonist
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (10)
ab120256 has been referenced in 10 publications.
- Naka A et al. Complementary networks of cortical somatostatin interneurons enforce layer specific control. Elife 8:N/A (2019). PubMed: 30883329
- Vaden JH et al. The readily-releasable pool dynamically regulates multivesicular release. Elife 8:N/A (2019). PubMed: 31364987
- Kim DW et al. Multimodal Analysis of Cell Types in a Hypothalamic Node Controlling Social Behavior. Cell 179:713-728.e17 (2019). PubMed: 31626771
- Bull FA et al. Morphine activation of mu opioid receptors causes disinhibition of neurons in the ventral tegmental area mediated by ß-arrestin2 and c-Src. Sci Rep 7:9969 (2017). PubMed: 28855588
- Turrini L et al. Optical mapping of neuronal activity during seizures in zebrafish. Sci Rep 7:3025 (2017). PubMed: 28596596
- Ferreira-Neto HC et al. ATP stimulates rat hypothalamic sympathetic neurons by enhancing AMPA receptor-mediated currents. J Neurophysiol 114:159-69 (2015). PubMed: 25904713
- Vashchinkina E et al. Neurosteroid Agonist at GABAA receptor induces persistent neuroplasticity in VTA dopamine neurons. Neuropsychopharmacology 39:727-37 (2014). PubMed: 24077066
- Bock R et al. Strengthening the accumbal indirect pathway promotes resilience to compulsive cocaine use. Nat Neurosci 16:632-8 (2013). PubMed: 23542690
- Mitra P & Brownstone RM An in vitro spinal cord slice preparation for recording from lumbar motoneurons of the adult mouse. J Neurophysiol 107:728-41 (2012). PubMed: 22031766
- Brady JD et al. Vesicular GABA release delays the onset of the Purkinje cell terminal depolarization without affecting tissue swelling in cerebellar slices during simulated ischemia. Neuroscience 168:108-17 (2010). PubMed: 20226232
