Key features and details
- Highly potent, selective brain penetrant D4 antagonist
- CAS Number: 866021-03-6
- Purity: > 99%
- Soluble in water to 100 mM
- Form / State: Solid
- Source: Synthetic
Product nameL-745870 trihydrochloride, brain penetrant D4 antagonist
DescriptionHighly potent, selective brain penetrant D4 antagonist
Highly potent and selective D4 antagonist (Ki values are 0.43, 2300 and 960 nM at D4, D3 and D2, respectively). Brain permeable. Inhibits cell death and shows neuroprotective effects.
Chemical name3-[4-(4-Chlorophenyl)piperazin-1-yl]-methyl-1H-pyrrolo[2,3-b]pyridine trihydrochloride
Storage instructionsStore at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in water to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab120598 has been referenced in 2 publications.
- Liang D et al. Identification of anthelmintic parbendazole as a therapeutic molecule for HNSCC through connectivity map-based drug repositioning. Acta Pharm Sin B 12:2429-2442 (2022). PubMed: 35646536
- Okimura K et al. Photoperiodic regulation of dopamine signaling regulates seasonal changes in retinal photosensitivity in mice. Sci Rep 11:1843 (2021). PubMed: 33469071