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    products/biochemicals/l-glutamate-excitatory-neurotransmitter-ab120049.pdf

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Neuroscience Neurotransmitter Amino Acids Glutamate
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L-Glutamate, excitatory neurotransmitter (ab120049)

  • Datasheet
  • SDS
  • COA
Submit a review Submit a question References (4)

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Chemical Structure - L-Glutamate, excitatory neurotransmitter (ab120049)
  • Immunocytochemistry/ Immunofluorescence - L-Glutamate, excitatory neurotransmitter (ab120049)

Key features and details

  • Excitatory neurotransmitter
  • CAS Number: 56-86-0
  • Soluble in 1 eq. NaOH to 100 mM and in water to 25mM
  • Form / State: Solid
  • Source: Synthetic

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Overview

  • Product name

    L-Glutamate, excitatory neurotransmitter
  • Description

    Excitatory neurotransmitter
  • Biological description

    Major excitatory neurotransmitter. Acts at glutamate receptors. Active in vivo.

  • CAS Number

    56-86-0
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (S)-2-Aminopentanedioic acid
  • Molecular weight

    147.13
  • Molecular formula

    C5H9NO4
  • PubChem identifier

    33032
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in 1 eq. NaOH to 100 mM and in water to 25mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    OC(=O)CC[C@H](N)C(=O)O
  • Source

    Synthetic

  • Research areas

    • Neuroscience
    • Neurotransmitter
    • Amino Acids
    • Glutamate
    • Neuroscience
    • Neurotransmission
    • Receptors / Channels
    • GPCR
    • Glutamate Receptors
    • Signal Transduction
    • Signaling Pathway
    • G Protein Signaling
    • GPCR
    • Biochemicals
    • Product Range
    • Just Add Water
    • Biochemicals
    • Chemical Type
    • Amino Acid
    • Biochemicals
    • Chemical Type
    • Biochemicals
    • Biochemicals
    • Pharmacology
    • Receptors & Transporters
    • Glutamate
    • Broad spectrum / non-selective
    • Agonists
    • Biochemicals
    • Research Area
    • Addiction
    • Glutamate
    • Broad spectrum / non-selective
    • Agonists
    • Biochemicals
    • Research Area
    • Alzheimer's Disease
    • Glutamate
    • Broad spectrum / non-selective
    • Agonists
    • Biochemicals
    • Research Area
    • Depression
    • Glutamate
    • Broad spectrum / non-selective
    • Agonists
    • Biochemicals
    • Research Area
    • Pain & inflammation
    • Glutamate
    • Broad spectrum / non-selective
    • Agonists
    • Biochemicals
    • Research Area
    • Parkinson's Disease
    • Glutamate
    • Broad spectrum / non-selective
    • Agonists
    • Biochemicals
    • Research Area
    • Schizophrenia
    • Glutamate
    • Broad spectrum / non-selective
    • Agonists
    • Biochemicals
    • Research Area
    • Stroke
    • Glutamate
    • Broad spectrum / non-selective
    • Agonists
    • Neuroscience
    • Processes

Applications

The Abpromise guarantee

Our Abpromise guarantee covers the use of ab120049 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Functional Studies
Use at an assay dependent concentration.
Notes
Functional Studies
Use at an assay dependent concentration.

Images

  • Chemical Structure - L-Glutamate, excitatory neurotransmitter (ab120049)
    Chemical Structure - L-Glutamate, excitatory neurotransmitter (ab120049)
    2D chemical structure image of ab120049, L-Glutamate, excitatory neurotransmitter
  • Immunocytochemistry/ Immunofluorescence - L-Glutamate, excitatory neurotransmitter (ab120049)
    Immunocytochemistry/ Immunofluorescence - L-Glutamate, excitatory neurotransmitter (ab120049)
    ab55051 staining GABA B receptor 1 in SK-N-SH cells treated with L-Glutamate (ab120049), by ICC/IF. Internalization of GABA B receptor 1 correlates with increased concentration of L-Glutamate, as described in literature.
    The cells were incubated at 37°C for 30 minutes in media containing different concentrations of ab120049 (L-Glutamate) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab55051 (1 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-mouse polyclonal antibody (ab96879) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

Datasheets and documents

  • SDS download

  • Datasheet download

    Download
  • COA

References (4)

Publishing research using ab120049? Please let us know so that we can cite the reference in this datasheet.

ab120049 has been referenced in 4 publications.

  • Guo C  et al. Purkinje cell outputs selectively inhibit a subset of unipolar brush cells in the input layer of the cerebellar cortex. Elife 10:N/A (2021). PubMed: 34369877
  • Mukherjee C  et al. Oligodendrocytes Provide Antioxidant Defense Function for Neurons by Secreting Ferritin Heavy Chain. Cell Metab 32:259-272.e10 (2020). PubMed: 32531201
  • Cheng K  et al. Calsyntenin-1 Negatively Regulates ICAM5 Accumulation in Postsynaptic Membrane and Influences Dendritic Spine Maturation in a Mouse Model of Fragile X Syndrome. Front Neurosci 13:1098 (2019). PubMed: 31680833
  • Pergner J & Kozmik Z Amphioxus photoreceptors - insights into the evolution of vertebrate opsins, vision and circadian rhythmicity. Int J Dev Biol 61:665-681 (2017). PubMed: 29319115

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