Latrunculin A (LAT-A), Actin polymerization inhibitor (ab144290)
Key features and details
- Actin polymerization inhibitor. Potent antiproliferative agent.
- CAS Number: 76343-93-6
- Purity: > 95%
- Soluble in ethanol to 10 mM and in DMSO to 10 mM
- Form / State: Solid
- Source: Cacospongia mycofijiensis
Overview
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Product name
Latrunculin A (LAT-A), Actin polymerization inhibitor -
Description
Actin polymerization inhibitor. Potent antiproliferative agent. -
Biological description
Actin polymerization inhibitor. Potent antiproliferative agent. Stabilizes monomeric G-actin. Shows greater potency than Latrunculin B (ab144291). Binds actin monomers near the nucleotide binding cleft with 1:1 stoichiometry. Inhibits growth of cancer cell lines (IC50 values are 142, 142, 142, 166 and 95 nM for A549, H522-T1, HT-29, U-937 and MDA-MB-43 cells respectively). Shows convulsant effects in vivo.
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Purity
> 95% -
CAS Number
76343-93-6 -
Chemical structure
Properties
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Chemical name
(4R)-4-[(1R,4Z,8E,10Z,12S,15R,17R)-17-Hydroxy-5,12-dimethyl-3-oxo-2,16-dioxabicyclo[13.3.1]nonadeca-4,8,10-trien-17-yl]-2-thiazolidinone -
Molecular weight
421.55 -
Molecular formula
C22H31NO5S -
PubChem identifier
445420 -
Storage instructions
Store at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions. -
Solubility overview
Soluble in ethanol to 10 mM and in DMSO to 10 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C[C@H]/1CC[C@@H]2C[C@H](C[C@@](O2)([C@@H]3CSC(=O)N3)O)OC(=O)/C=C(\CC/C=C/C=C1)/C -
Source
Cacospongia mycofijiensis
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Research areas
Images
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Chemical Structure - Latrunculin A (LAT-A), Actin polymerization inhibitor (ab144290)2D chemical structure image of ab144290, Latrunculin A (LAT-A), Actin polymerization inhibitor
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (18)
ab144290 has been referenced in 18 publications.
- Li B et al. Mechanical phenotyping reveals unique biomechanical responses in retinoic acid-resistant acute promyelocytic leukemia. iScience 25:103772 (2022). PubMed: 35141508
- Kasioulis I et al. A lateral protrusion latticework connects neuroepithelial cells and is regulated during neurogenesis. J Cell Sci 135:N/A (2022). PubMed: 35217862
- de Los Ángeles Juricic Urzúa M et al. The dendritic ERGIC: Microtubule and actin cytoskeletons participate in stop-and-go movement of mobile carriers between stable structures. Traffic 23:174-187 (2022). PubMed: 35075729
- Li B et al. Evaluating sources of technical variability in the mechano-node-pore sensing pipeline and their effect on the reproducibility of single-cell mechanical phenotyping. PLoS One 16:e0258982 (2021). PubMed: 34695165
- Lim Y et al. ß2-adrenergic receptor regulates ER-mitochondria contacts. Sci Rep 11:21477 (2021). PubMed: 34728663
