Latrunculin B, actin polymerization inhibitor (ab144291)
Key features and details
- Cell-permeable actin polymerization inhibitor
- CAS Number: 76343-94-7
- Purity: > 96%
Soluble in DMSO (25 mg/ml) or ethanol (25 mg/ml)
- Form / State: Solid
- Source: Latrunculia magnifica
Overview
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Product name
Latrunculin B, actin polymerization inhibitor -
Description
Cell-permeable actin polymerization inhibitor -
Purity
> 96% -
CAS Number
76343-94-7 -
Chemical structure
Properties
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Chemical name
(4R)-4-[(1R,4S,5Z,9Z,13R,15R)-15-Hydroxy-4,9-dimethyl-11-oxo-12,16-dioxabicyclo[11.3.1]heptadeca-5,9-dien-15-yl]-1,3-thiazolidin-2-one
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Molecular weight
395.51 -
Molecular formula
C20H29NO5S -
PubChem identifier
6436219 -
Storage instructions
Store at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions. -
Solubility overview
Soluble in DMSO (25 mg/ml) or ethanol (25 mg/ml)
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Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C[C@H]/1CC[C@@H]2C[C@H](C[C@@](O2)([C@@H]3CSC(=O)N3)O)OC(=O)/C=C(\CC/C=C1)/C -
Source
Latrunculia magnifica
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Research areas
Images
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Chemical Structure - Latrunculin B, actin polymerization inhibitor (ab144291)2D chemical structure image of ab144291, Latrunculin B, actin polymerization inhibitor
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (25)
ab144291 has been referenced in 25 publications.
- Fang XD et al. Host casein kinase 1-mediated phosphorylation modulates phase separation of a rhabdovirus phosphoprotein and virus infection. Elife 11:N/A (2022). PubMed: 35191833
- Williams TD et al. Actin remodelling controls proteasome homeostasis upon stress. Nat Cell Biol 24:1077-1087 (2022). PubMed: 35739319
- Bayati A et al. Rapid macropinocytic transfer of a-synuclein to lysosomes. Cell Rep 40:111102 (2022). PubMed: 35858558
- Sun Y et al. Plant egg cell fate determination depends on its exact position in female gametophyte. Proc Natl Acad Sci U S A 118:N/A (2021). PubMed: 33597298
- Hurst V et al. Cytoskeleton integrity influences XRCC1 and PCNA dynamics at DNA damage. Mol Biol Cell 32:br6 (2021). PubMed: 34379448