LY 367385, mGlu1a antagonist (ab120067)
Key features and details
- mGlu1a antagonist
- CAS Number: 198419-91-9
- Soluble in 1.1 eq. NaOH to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
LY 367385, mGlu1a antagonist -
Description
mGlu1a antagonist -
Biological description
Potent, selective mGlu1a antagonist. Neuroprotective and anticonvulsant in vivo.
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CAS Number
198419-91-9 -
Chemical structure
Properties
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Chemical name
(S)-(+)-α-Amino-4-carboxy-2-methylbenzeneacetic acid -
Molecular weight
209.20 -
Molecular formula
C10H11NO4 -
PubChem identifier
5311261 -
Storage instructions
Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in 1.1 eq. NaOH to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Cc1cc(ccc1[C@H](N)C(=O)O)C(=O)O -
Source
Synthetic
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Research areas
Images
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Chemical Structure - LY 367385, mGlu1a antagonist (ab120067)2D chemical structure image of ab120067, LY 367385, mGlu1a antagonist
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (11)
ab120067 has been referenced in 11 publications.
- Robin LM et al. Astroglial CB1 Receptors Determine Synaptic D-Serine Availability to Enable Recognition Memory. Neuron 98:935-944.e5 (2018). PubMed: 29779943
- Colavita M et al. Layer-specific potentiation of network GABAergic inhibition in the CA1 area of the hippocampus. Sci Rep 6:28454 (2016). PubMed: 27345695
- Eng AG et al. Transduction of group I mGluR-mediated synaptic plasticity by ß-arrestin2 signalling. Nat Commun 7:13571 (2016). PubMed: 27886171
- Bragina L et al. Differential expression of metabotropic glutamate and GABA receptors at neocortical glutamatergic and GABAergic axon terminals. Front Cell Neurosci 9:345 (2015). PubMed: 26388733
- Younts TJ et al. CA1 pyramidal cell theta-burst firing triggers endocannabinoid-mediated long-term depression at both somatic and dendritic inhibitory synapses. J Neurosci 33:13743-57 (2013). PubMed: 23966696