Mdivi-1, Drp1 inhibitor (ab144589)
Key features and details
- Selective, cell-permeable mitochondrial division Drp1 inhibitor
- CAS Number: 338967-87-6
- Purity: > 98%
- Soluble in DMSO to 50 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Mdivi-1, Drp1 inhibitor -
Description
Selective, cell-permeable mitochondrial division Drp1 inhibitor -
Purity
> 98% -
CAS Number
338967-87-6 -
Chemical structure
Properties
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Chemical name
3-(2,4-Dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone -
Molecular weight
353.23 -
Molecular formula
C15H10Cl2N2O2S -
PubChem identifier
3825829 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 50 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
COC1=C(C=C(C(=C1)N2C(=O)C3=CC=CC=C3NC2=S)Cl)Cl -
Source
Synthetic
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Research areas
Images
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Chemical Structure - Mdivi-1, Drp1 inhibitor (ab144589)2D chemical structure image of ab144589, Mdivi-1, Drp1 inhibitor
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (7)
ab144589 has been referenced in 7 publications.
- Zhang L et al. Effect of the interference with DRP1 expression on the biological characteristics of glioma stem cells. Exp Ther Med 22:696 (2021). PubMed: 33986860
- Tusskorn O et al. Mitochondrial division inhibitor-1 potentiates cisplatin-induced apoptosis via the mitochondrial death pathway in cholangiocarcinoma cells. Biomed Pharmacother 111:109-118 (2019). PubMed: 30579250
- Yang SK et al. Mitochondria-Targeted Peptide SS31 Attenuates Renal Tubulointerstitial Injury via Inhibiting Mitochondrial Fission in Diabetic Mice. Oxid Med Cell Longev 2019:2346580 (2019). PubMed: 31281569
- Park HS et al. Swine Influenza Virus Induces RIPK1/DRP1-Mediated Interleukin-1 Beta Production. Viruses 10:N/A (2018). PubMed: 30096906
- Hang W et al. Berberine Ameliorates High Glucose-Induced Cardiomyocyte Injury via AMPK Signaling Activation to Stimulate Mitochondrial Biogenesis and Restore Autophagic Flux. Front Pharmacol 9:1121 (2018). PubMed: 30337876
- Yin J et al. Doxorubicin-induced mitophagy and mitochondrial damage is associated with dysregulation of the PINK1/parkin pathway. Toxicol In Vitro 51:1-10 (2018). PubMed: 29729358
- Shen Z et al. PARK2-dependent mitophagy induced by acidic postconditioning protects against focal cerebral ischemia and extends the reperfusion window. Autophagy 13:473-485 (2017). PubMed: 28103118