Key features and details
- NMDA antagonist, ion channel site
- CAS Number: 41100-52-1
- Soluble in water to 100 mM
- Form / State: Solid
- Source: Synthetic
Product nameMemantine hydrochloride, NMDA antagonist
DescriptionNMDA antagonist, ion channel site
Antagonist at the NMDA receptor. Acts as a fast, voltage-dependent, open channel NMDA receptor blocker. Used in the clinic to treat Alzheimer's disease. Cognitive enhancer and anxiolytic in vivo.
Also available in simple stock solutions (ab146687) - add 1 ml of water to get an exact, ready-to-use concentration.
Chemical name3,5-Dimethyl-1-adamantanamine hydrochloride
Storage instructionsStore at Room Temperature. The product can be stored for up to 12 months.
Solubility overviewSoluble in water to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
2D chemical structure image of ab120249, Memantine hydrochloride, NMDA antagonist
Averaged time courses of NMDA receptor-isolated synaptic field potentials in dorsal lateral bed nucleus of the stria terminalis following 60 minutes of memantine (5 or 30 μM; ab120249) in naive adult male C57BL/6J mice.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab120249 has been referenced in 1 publication.
- Wills TA et al. GluN2B subunit deletion reveals key role in acute and chronic ethanol sensitivity of glutamate synapses in bed nucleus of the stria terminalis. Proc Natl Acad Sci U S A 109:E278-87 (2012). PubMed: 22219357