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Mevastatin, HMG-CoA reductase inhibitor (ab120652)

  • Datasheet
  • SDS
  • COA
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Chemical Structure - Mevastatin, HMG-CoA reductase inhibitor (ab120652)
  • Immunocytochemistry/ Immunofluorescence - Mevastatin, HMG-CoA reductase inhibitor (ab120652)

Key features and details

  • Potent HMG-CoA reductase inhibitor
  • CAS Number: 73573-88-3
  • Purity: > 98%
  • Soluble in ethanol to 10 mM and DMSO to 100 mM
  • Form / State: Solid
  • Source: Synthetic

Overview

  • Product name

    Mevastatin, HMG-CoA reductase inhibitor
  • Description

    Potent HMG-CoA reductase inhibitor
  • Alternative names

    • Compactin
  • Biological description

    Potent HMG-CoA reductase inhibitor. Proapoptotic, able to arrest cells in G1 by down-regulation of CDK4, CDK6 and cyclin D1 and up-regulation of p21 and p27.

  • Purity

    > 98%
  • CAS Number

    73573-88-3
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (2S)-2-Methyl-(1S,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-7-methyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl butanoate
  • Molecular weight

    390.52
  • Molecular formula

    C23H34O5
  • PubChem identifier

    64715
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol to 10 mM and DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

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    • HMG-CoA reductase

Applications

The Abpromise guarantee

Our Abpromise guarantee covers the use of ab120652 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Functional Studies
Use at an assay dependent concentration.
Notes
Functional Studies
Use at an assay dependent concentration.

Images

  • Chemical Structure - Mevastatin, HMG-CoA reductase inhibitor (ab120652)
    Chemical Structure - Mevastatin, HMG-CoA reductase inhibitor (ab120652)
    2D chemical structure image of ab120652, Mevastatin, HMG-CoA reductase inhibitor
  • Immunocytochemistry/ Immunofluorescence - Mevastatin, HMG-CoA reductase inhibitor (ab120652)
    Immunocytochemistry/ Immunofluorescence - Mevastatin, HMG-CoA reductase inhibitor (ab120652)
    ab90529 staining cytochrome C in HepG2 cells treated with mevastatin (ab120652), by ICC/IF. Increase of cytochrome C expression correlates with increased concentration of mevastatin, as described in literature.
    The cells were incubated at 37°C for 4 hours in media containing different concentrations of ab120652 (mevastatin) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab90529 (1 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

Datasheets and documents

  • SDS download

  • Datasheet download

    Download
  • COA

References (4)

Publishing research using ab120652? Please let us know so that we can cite the reference in this datasheet.

ab120652 has been referenced in 4 publications.

  • Brown M  et al. The differential effects of statins on the metastatic behaviour of prostate cancer. Br J Cancer : (2012). PubMed: 22531631
  • Yap F  et al. Mechanism of AMPK suppression of LXR-dependent Srebp-1c transcription. Int J Biol Sci 7:645-50 (2011). PubMed: 21647332
  • Evangelopoulos ME  et al. A role of nitric oxide in neurite outgrowth of neuroblastoma cells triggered by mevastatin or serum reduction. Neurosci Lett 468:28-33 (2010). PubMed: 19853642
  • Wächtershäuser A  et al. HMG-CoA reductase inhibitor mevastatin enhances the growth inhibitory effect of butyrate in the colorectal carcinoma cell line Caco-2. Carcinogenesis 22:1061-7 (2001). PubMed: 11408350

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