Minocycline hydrochloride, Antibiotic (ab120661)
Key features and details
- Antibiotic. Demonstrates multiple effects.
- CAS Number: 13614-98-7
- Purity: > 98%
- Soluble in DMSO to 100 mM (with warming) and in water to 25 mM (with warming)
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Minocycline hydrochloride, Antibiotic -
Description
Antibiotic. Demonstrates multiple effects. -
Biological description
Antibiotic. Demonstrates anti-inflammatory, antiapoptotic, antioxidant and neuroprotective effects. Blood-brain barrier permeable. Matrix metalloproteinase (MMP) inhibitor (IC50 = 290 μM at stromelysin (MMP-3).
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Purity
> 98% -
CAS Number
13614-98-7 -
Chemical structure
Properties
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Chemical name
[4S-(4α,4aα,5aα,12aα)]-4,7-Bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a,tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide hydrochloride -
Molecular weight
493.94 -
Molecular formula
C23H27N3O7.HCl -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM (with warming) and in water to 25 mM (with warming) -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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Source
Synthetic
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Research areas
- Biochemicals
- Pharmacology
- Signaling
- Signal transduction
- Nitric oxide & oxidative stress
- Antioxidants
- Biochemicals
- Research Area
- Alzheimer's Disease
- Signaling
- Signal transduction
- Nitric oxide signaling
- Antioxidants
- Biochemicals
- Research Area
- Diabetes
- Signaling
- Signal transduction
- Nitric oxide signaling
- Antioxidants
- Biochemicals
- Research Area
- Hypertension
- Signaling
- Signal transduction
- Nitric oxide signaling
- Antioxidants
Images
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Chemical Structure - Minocycline hydrochloride, Antibiotic (ab120661)2D chemical structure image of ab120661, Minocycline hydrochloride, Antibiotic
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (2)
ab120661 has been referenced in 2 publications.
- Otsu Y et al. Functional Principles of Posterior Septal Inputs to the Medial Habenula. Cell Rep 22:693-705 (2018). PubMed: 29346767
- Li TF et al. Ester Hydrolysis Differentially Reduces Aconitine-Induced Anti-hypersensitivity and Acute Neurotoxicity: Involvement of Spinal Microglial Dynorphin Expression and Implications for Aconitum Processing. Front Pharmacol 7:367 (2016). PubMed: 27761113