Mirin, MRN-ATM complex inhibitor (ab141182)
Key features and details
- MRN-ATM complex inhibitor
- CAS Number: 299953-00-7
- Purity: > 99%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Mirin, MRN-ATM complex inhibitor -
Description
MRN-ATM complex inhibitor -
Biological description
Mre11-Rad50-Nbs1 (MRN)-ATM complex inhibitor that blocks the 3' to 5' exonuclease activity associated with Mre11. Prevents ATM activation in response to double strand breaks (IC50= 12 μM) and induces G2 arrest in vitro.
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Purity
> 99% -
CAS Number
299953-00-7 -
Chemical structure
Properties
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Chemical name
2-Amino-5-[(4-hydroxyphenyl)methylene]-4(5H)-thiazolone -
Molecular weight
220.25 -
Molecular formula
C10H8N2O2S -
PubChem identifier
1206243 -
Storage instructions
Store at +4°C. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
O=C2NC(=N)S/C2=C\c1ccc(O)cc1 -
Source
Synthetic
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Research areas
Images
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Chemical Structure - Mirin, MRN-ATM complex inhibitor (ab141182)2D chemical structure image of ab141182, Mirin, MRN-ATM complex inhibitor
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (2)
ab141182 has been referenced in 2 publications.
- Petsalaki E & Zachos G An ATM-Chk2-INCENP pathway activates the abscission checkpoint. J Cell Biol 220:N/A (2021). PubMed: 33355621
- Isobe SY et al. Protein phosphatase 1 acts as a RIF1 effector to suppress DSB resection prior to Shieldin action. Cell Rep 36:109383 (2021). PubMed: 34260925