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    products/biochemicals/mirin-mrn-atm-complex-inhibitor-ab141182.pdf

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Biochemicals Chemical Type Biochemicals
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Mirin, MRN-ATM complex inhibitor (ab141182)

  • Datasheet
  • SDS
  • COA
Submit a review Q&A (1)References (2)

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Chemical Structure - Mirin, MRN-ATM complex inhibitor (ab141182)

    Key features and details

    • MRN-ATM complex inhibitor
    • CAS Number: 299953-00-7
    • Purity: > 99%
    • Soluble in DMSO to 100 mM
    • Form / State: Solid
    • Source: Synthetic

    Overview

    • Product name

      Mirin, MRN-ATM complex inhibitor
    • Description

      MRN-ATM complex inhibitor
    • Biological description

      Mre11-Rad50-Nbs1 (MRN)-ATM complex inhibitor that blocks the 3' to 5' exonuclease activity associated with Mre11. Prevents ATM activation in response to double strand breaks (IC50= 12 μM) and induces G2 arrest in vitro.

    • Purity

      > 99%
    • CAS Number

      299953-00-7
    • Chemical structure

      Chemical Structure

    Properties

    • Chemical name

      2-Amino-5-[(4-hydroxyphenyl)methylene]-4(5H)-thiazolone
    • Molecular weight

      220.25
    • Molecular formula

      C10H8N2O2S
    • PubChem identifier

      1206243
    • Storage instructions

      Store at +4°C. The product can be stored for up to 12 months.
    • Solubility overview

      Soluble in DMSO to 100 mM
    • Handling

      Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

      Refer to SDS for further information

      Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

    • SMILES

      O=C2NC(=N)S/C2=C\c1ccc(O)cc1
    • Source

      Synthetic

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    Images

    • Chemical Structure - Mirin, MRN-ATM complex inhibitor (ab141182)
      Chemical Structure - Mirin, MRN-ATM complex inhibitor (ab141182)
      2D chemical structure image of ab141182, Mirin, MRN-ATM complex inhibitor

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • SDS download

    • Datasheet download

      Download
    • COA

    References (2)

    Publishing research using ab141182? Please let us know so that we can cite the reference in this datasheet.

    ab141182 has been referenced in 2 publications.

    • Petsalaki E & Zachos G An ATM-Chk2-INCENP pathway activates the abscission checkpoint. J Cell Biol 220:N/A (2021). PubMed: 33355621
    • Isobe SY  et al. Protein phosphatase 1 acts as a RIF1 effector to suppress DSB resection prior to Shieldin action. Cell Rep 36:109383 (2021). PubMed: 34260925

    Customer reviews and Q&As

    Show All Reviews Q&A
    Submit a review Submit a question

    Question

    I've ordered and received a aliquot of mirin, the MRE11 inhibitor. On the bottle, it states that the MW of mirin is 229.25 daltons, however on the safety sheet and online is states 220.25. Can you please fix this?

    Read More

    Abcam community

    Verified customer

    Asked on Apr 28 2016

    Answer

    Many of the biochemicals including Mirin (ab141182) will have water crysalization content. The label on the vial includes the moelecuar weight of the crystalized water for that particular batch you have purchased.

    The datasheet and SDS have the molecular weight of just the biochemical itsefl.

    Read More

    Sam Washer

    Abcam Scientific Support

    Answered on Apr 28 2016

    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
    For licensing inquiries, please contact partnerships@abcam.com

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