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  1. Link

    products/biochemicals/mitmab-dynamin-i-and-dynamin-ii-inhibitor-ab120466.pdf

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Signal Transduction Protein Trafficking Vesicle Transport Regulation
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MiTMAB™, dynamin I and dynamin II inhibitor (ab120466)

  • Datasheet
  • SDS
  • COA
Submit a review Submit a question References (8)

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Chemical Structure - MiTMAB™, dynamin I and dynamin II inhibitor (ab120466)
  • Immunocytochemistry/ Immunofluorescence - MiTMAB™, dynamin I and dynamin II inhibitor (ab120466)

Key features and details

  • Cell-permeable dynamin I and dynamin II inhibitor
  • CAS Number: 1119-97-7
  • Soluble in water to 100 mM
  • Form / State: Solid
  • Source: Synthetic

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Overview

  • Product name

    MiTMAB™, dynamin I and dynamin II inhibitor
  • Description

    Cell-permeable dynamin I and dynamin II inhibitor
  • Biological description

    Cell-permeable dynamin I and dynamin II inhibitor (IC50 values are 3.1 and 8.4 µM for inhibition of dynamin I and dynamin II GTPase, respectively). Targets the pleckstrin homology (PH) (lipid binding) domain. Competitive with phospholipid and non-competitive with GTP. Inhibits receptor-mediated and synaptic vesicle endocytosis (IC50 values are 19.9 and 2.2 µM, respectively). Inhibits cancer cell growth.

  • General notes

    Sold under exclusive licence from Children's Medical Research Institute and Newcastle Innovation Ltd. MiTMAB™ and OcTMAB™ are trademarks of Children's Medical Research Institute and Newcastle Innovation Ltd.
  • CAS Number

    1119-97-7
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    Tetradecyltrimethylammonium bromide
  • Molecular weight

    336.40
  • Molecular formula

    C17H38BrN
  • PubChem identifier

    14250
  • Storage instructions

    Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Toxic, refer to SDS for further information.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    [Br-].C[N+](C)(C)CCCCCCCCCCCCCC
  • Source

    Synthetic

  • Research areas

    • Signal Transduction
    • Protein Trafficking
    • Vesicle Transport
    • Regulation
    • Neuroscience
    • Cell Type Marker
    • Neuron marker
    • Synapse marker
    • Biochemicals
    • Product Range
    • Just Add Water
    • Biochemicals
    • Chemical Type
    • Biochemicals
    • Biochemicals
    • Pharmacology
    • Enzymes
    • ATPase & GTPase
    • Inhibitors
    • Biochemicals
    • Pharmacology
    • Signaling
    • Endocytosis & exocytosis
    • Dynamin
    • Biochemicals
    • Research Area
    • Heart disease
    • Signaling
    • Endocytosis & exocytosis
    • Dynamin
    • Biochemicals
    • Research Area
    • Pain & inflammation
    • Signaling
    • Endocytosis & exocytosis
    • Dynamin
    • Biochemicals
    • Research Area
    • Alzheimer's Disease
    • Signaling
    • Endocytosis & exocytosis
    • Dynamin
    • Biochemicals
    • Research Area
    • Diabetes
    • Signaling
    • Endocytosis & exocytosis
    • Dynamin
    • Biochemicals
    • Research Area
    • Hypertension
    • Signaling
    • Endocytosis & exocytosis
    • Dynamin
    • Biochemicals
    • Research Area
    • Obesity
    • Signaling
    • Endocytosis & exocytosis
    • Dynamin
    • Biochemicals
    • Research Area
    • Respiratory disease
    • Signaling
    • Endocytosis & exocytosis
    • Dynamin
    • Biochemicals
    • Research Area
    • Stroke
    • Signaling
    • Endocytosis & exocytosis
    • Dynamin
    • Neuroscience
    • Processes

Applications

The Abpromise guarantee

Our Abpromise guarantee covers the use of ab120466 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Functional Studies
Use at an assay dependent concentration.
Notes
Functional Studies
Use at an assay dependent concentration.

Images

  • Chemical Structure - MiTMAB™, dynamin I and dynamin II inhibitor (ab120466)
    Chemical Structure - MiTMAB™, dynamin I and dynamin II inhibitor (ab120466)
    2D chemical structure image of ab120466, MiTMAB™, dynamin I and dynamin II inhibitor
  • Immunocytochemistry/ Immunofluorescence - MiTMAB™, dynamin I and dynamin II inhibitor (ab120466)
    Immunocytochemistry/ Immunofluorescence - MiTMAB™, dynamin I and dynamin II inhibitor (ab120466)
    ab66705 staining PAI1 in HeLa cells treated with MiTMAB™ (ab120466), by ICC/IF. Increase in PAI1 expression correlates with increased concentration of MiTMAB™, as described in literature.
    The cells were incubated at 37°C for 24h in media containing different concentrations of ab120466 (MiTMAB™) in DMSO, fixed with 100% methanol for 5 minutes at -20°C and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab66705 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

Datasheets and documents

  • SDS download

  • Datasheet download

    Download
  • COA

References (8)

Publishing research using ab120466? Please let us know so that we can cite the reference in this datasheet.

ab120466 has been referenced in 8 publications.

  • Štimac I  et al. Dynamin Inhibitors Prevent the Establishment of the Cytomegalovirus Assembly Compartment in the Early Phase of Infection. Life (Basel) 11:N/A (2021). PubMed: 34575026
  • Wang D  et al. ERK is involved in the differentiation and function of dimethyl sulfoxide-induced HL-60 neutrophil-like cells, which mimic inflammatory neutrophils. Int Immunopharmacol 84:106510 (2020). PubMed: 32361568
  • Metwally H  et al. Noncanonical STAT1 phosphorylation expands its transcriptional activity into promoting LPS-induced IL-6 and IL-12p40 production. Sci Signal 13:N/A (2020). PubMed: 32209697
  • Aoto M  et al. Transferrin receptor 1 is required for enucleation of mouse erythroblasts during terminal differentiation. FEBS Open Bio 9:291-303 (2019). PubMed: 30761254
  • Pfanzelter J  et al. Septins suppress the release of vaccinia virus from infected cells. J Cell Biol 217:2911-2929 (2018). PubMed: 29921601
  • Grassart A  et al. Actin and dynamin2 dynamics and interplay during clathrin-mediated endocytosis. J Cell Biol 205:721-35 (2014). PubMed: 24891602
  • Fiore VF  et al. Dynamic catch of a Thy-1-a5ß1+syndecan-4 trimolecular complex. Nat Commun 5:4886 (2014). PubMed: 25216363
  • Nimitvilai S  et al. Reversal of dopamine D2 agonist-induced inhibition of ventral tegmental area neurons by Gq-linked neurotransmitters is dependent on protein kinase C, G protein-coupled receptor kinase, and dynamin. J Pharmacol Exp Ther 344:253-63 (2013). PubMed: 23019137

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