MitoTEMPOL, mitochondria-targeted antioxidant agent (ab144644)
Key features and details
- Mitochondria-targeted antioxidant agent
- CAS Number: 1101113-39-6
- Purity: > 98%
Soluble in water to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
MitoTEMPOL, mitochondria-targeted antioxidant agent -
Description
Mitochondria-targeted antioxidant agent -
Purity
> 98% -
CAS Number
1101113-39-6 -
Chemical structure
Properties
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Chemical name
2,2,6,6-Tetramethyl-4-[[5-(triphenylphosphonio)pentyl]oxy]-1-piperidinyloxy bromide
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Molecular weight
583.57 -
Molecular formula
C32H42BrNO2P -
PubChem identifier
132285183 -
Storage instructions
Store at -20°C. Store In the Dark. Store under desiccating conditions. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes. -
Solubility overview
Soluble in water to 100 mM
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Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC1(CC(CC(N1[O])(C)C)OCCCCC[P+](C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4)C.[Br-] -
Source
Synthetic
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Research areas
Images
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Chemical Structure - MitoTEMPOL, mitochondria-targeted antioxidant agent (ab144644)2D chemical structure image of ab144644, MitoTEMPOL, mitochondria-targeted antioxidant agent
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (5)
ab144644 has been referenced in 5 publications.
- Supinski GS et al. MitoTEMPOL, a Mitochondrial Targeted Antioxidant, Prevents Sepsis Induced Diaphragm Dysfunction. Am J Physiol Lung Cell Mol Physiol N/A:N/A (2020). PubMed: 32460519
- Xu SJ et al. Flavonoids from Rosaroxburghii Tratt prevent reactive oxygen species-mediated DNA damage in thymus cells both combined with and without PARP-1 expression after exposure to radiation in vivo. Aging (Albany NY) 12:16368-16389 (2020). PubMed: 32862153
- Liao Y et al. Endoplasmic Reticulum Stress Induces Macrophages to Produce IL-1ß During Mycobacterium bovis Infection via a Positive Feedback Loop Between Mitochondrial Damage and Inflammasome Activation. Front Immunol 10:268 (2019). PubMed: 30846986
- Lin Z et al. Hydrogen sulfide attenuates oxidative stress-induced NLRP3 inflammasome activation via S-sulfhydrating c-Jun at Cys269 in macrophages. Biochim Biophys Acta N/A:N/A (2018). PubMed: 29859240
- Zhao Y et al. Alisol B 23-acetate induces autophagic-dependent apoptosis in human colon cancer cells via ROS generation and JNK activation. Oncotarget 8:70239-70249 (2017). PubMed: 29050275