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    products/biochemicals/monastrol-cell-permeable-mitosis-inhibitor-ab141087.pdf

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Signal Transduction Cytoskeleton / ECM Cytoskeleton Motor Proteins Kinesin-like
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Monastrol, cell permeable mitosis inhibitor (ab141087)

  • Datasheet
  • SDS
  • COA
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Chemical Structure - Monastrol, cell permeable mitosis inhibitor (ab141087)

    Key features and details

    • Potent and cell permeable mitosis inhibitor. Kinesin Eg5 inhibitor.
    • CAS Number: 329689-23-8
    • Purity: > 99%
    • Soluble in DMSO to 100 mM and in ethanol to 100 mM
    • Form / State: Solid
    • Source: Synthetic

    Overview

    • Product name

      Monastrol, cell permeable mitosis inhibitor
    • Description

      Potent and cell permeable mitosis inhibitor. Kinesin Eg5 inhibitor.
    • Purity

      > 99%
    • CAS Number

      329689-23-8
    • Chemical structure

      Chemical Structure

    Properties

    • Chemical name

      1,2,3,4-Tetrahydro-4-(3-hydroxyphenyl)-6-methyl-2-thioxo-5-pyrimidinecarboxylic acid ethyl ester
    • Molecular weight

      292.35
    • Molecular formula

      C14H16N2O3S
    • PubChem identifier

      2987927
    • Storage instructions

      Store at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions.
    • Solubility overview

      Soluble in DMSO to 100 mM and in ethanol to 100 mM
    • Handling

      Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

      Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

    • SMILES

      O=C(OCC)C2=C(C)NC(=S)NC2c1cc(O)ccc1
    • Source

      Synthetic

    • Research areas

      • Signal Transduction
      • Cytoskeleton / ECM
      • Cytoskeleton
      • Motor Proteins
      • Kinesin-like
      • Cardiovascular
      • Lipids / Lipoproteins
      • Lipid Metabolism
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      • Alcohol metabolism
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      • Mitochondrial Metabolism
      • Cytochromes
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      • Research Area
      • Heart disease
      • Signaling
      • Cytoskeleton & motor proteins
      • Inhibitors
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      • Research Area
      • Heart disease
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      • Ca2+-ATPase
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      • Research Area
      • Pain & inflammation
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      • Inhibitors
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      • Research Area
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      • Cytoskeleton & motor proteins
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      • Hypertension
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      • Stroke
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      • Tubulin
      • Biochemicals
      • Research Area
      • Cancer
      • Cytoskeleton & motor proteins
      • Kinesin

    Images

    • Chemical Structure - Monastrol, cell permeable mitosis inhibitor (ab141087)
      Chemical Structure - Monastrol, cell permeable mitosis inhibitor (ab141087)
      2D chemical structure image of ab141087, Monastrol, cell permeable mitosis inhibitor

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • SDS download

    • Datasheet download

      Download
    • COA

    References (2)

    Publishing research using ab141087? Please let us know so that we can cite the reference in this datasheet.

    ab141087 has been referenced in 2 publications.

    • Walton CC  et al. Primary neurons can enter M-phase. Sci Rep 9:4594 (2019). PubMed: 30872646
    • Cho YC  et al. Cell cycle-dependent Cdc25C phosphatase determines cell survival by regulating apoptosis signal-regulating kinase 1. Cell Death Differ 22:1605-17 (2015). PubMed: 25633196

    Customer reviews and Q&As

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