N omega-Nitro-L-arginine methyl ester hydrochloride (L-NAME), NOS inhibitor (ab120136)
Key features and details
- NOS inhibitor
- CAS Number: 51298-62-5
- Soluble in water to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
N omega-Nitro-L-arginine methyl ester hydrochloride (L-NAME), NOS inhibitor -
Description
NOS inhibitor -
Alternative names
- L-NAME
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Biological description
Cell-permeable NOS inhibitor. More soluble analog of arginine. (pIC50 values are 4.3, 5.7 and 5.6 at human iNOS, nNOA and eNOS, respectively).
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CAS Number
51298-62-5 -
Chemical structure
Properties
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Chemical name
Nω-Nitro-L-arginine methyl ester hydrochloride -
Molecular weight
269.69 -
Molecular formula
C7H15N5O4.HCl -
PubChem identifier
135193 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Cl.N[C@@H](CCCNC(=N)N[N+]([O-])=O)C(=O)OC -
Source
Synthetic
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Research areas
- Biochemicals
- Pharmacology
- Signaling
- Signal transduction
- Nitric oxide & oxidative stress
- NOS
- Inhibitors
- Biochemicals
- Research Area
- Alzheimer's Disease
- Signaling
- Signal transduction
- Nitric oxide signaling
- NOS
- Inhibitors
- Biochemicals
- Research Area
- Diabetes
- Signaling
- Signal transduction
- Nitric oxide signaling
- NOS
- Inhibitors
- Biochemicals
- Research Area
- Hypertension
- Signaling
- Signal transduction
- Nitric oxide signaling
- NOS
- Inhibitors
- Biochemicals
- Research Area
- Obesity
- Signaling
- Signal transduction
- Nitric oxide signaling
- NOS
- Inhibitors
Images
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Chemical Structure - N omega-Nitro-L-arginine methyl ester hydrochloride (L-NAME), NOS inhibitor (ab120136)2D chemical structure image of ab120136, N omega-Nitro-L-arginine methyl ester hydrochloride (L-NAME), NOS inhibitor
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (8)
ab120136 has been referenced in 8 publications.
- Pal S et al. Skeletal restoration by phosphodiesterase 5 inhibitors in osteopenic mice: Evidence of osteoanabolic and osteoangiogenic effects of the drugs. Bone 135:115305 (2020). PubMed: 32126313
- Liu W et al. Repeated Nitrous Oxide Exposure Exerts Antidepressant-Like Effects Through Neuronal Nitric Oxide Synthase Activation in the Medial Prefrontal Cortex. Front Psychiatry 11:837 (2020). PubMed: 33088274
- Ren H et al. Chondrocyte apoptosis in rat mandibular condyles induced by dental occlusion due to mitochondrial damage caused by nitric oxide. Arch Oral Biol 101:108-121 (2019). PubMed: 30927660
- Tabansky I et al. Molecular profiling of reticular gigantocellularis neurons indicates that eNOS modulates environmentally dependent levels of arousal. Proc Natl Acad Sci U S A 115:E6900-E6909 (2018). PubMed: 29967172
- Barbaro NR et al. Dendritic Cell Amiloride-Sensitive Channels Mediate Sodium-Induced Inflammation and Hypertension. Cell Rep 21:1009-1020 (2017). PubMed: 29069584
- Belvedere R et al. The Pharmaceutical Device Prisma®Skin Promotes in Vitro Angiogenesis through Endothelial to Mesenchymal Transition during Skin Wound Healing. Int J Mol Sci 18:N/A (2017). PubMed: 28757565
- Marangoni A et al. Infection of human monocytes by Chlamydia pneumoniae and Chlamydia trachomatis: an in vitro comparative study. BMC Res Notes 7:230 (2014). PubMed: 24721461
- Foster JD et al. Nitric oxide-mediated modulation of the murine locomotor network. J Neurophysiol 111:659-74 (2014). PubMed: 24259545