Nefazodone hydrochloride, 5-HT2A antagonist (ab120587)
Key features and details
- Potent 5-HT2A antagonist
- CAS Number: 82752-99-6
- Soluble in DMSO to 25 mM, in ethanol to 10 mM and in 1 eq. HCl to 10 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Nefazodone hydrochloride, 5-HT2A antagonist -
Description
Potent 5-HT2A antagonist -
Biological description
Potent 5-HT2A receptor antagonist (Ki = 7.1 nM for inhibition of [3H] ketanserin binding in rat cortex). Additionally blocks α1 adrenoceptors (Ki values are 5.5 and 84 nM at α1 and α2, respectively). Acts as a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI) (Ki values are 220 and 555 nM at rat SERT and NET, respectively). Antidepressant.
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CAS Number
82752-99-6 -
Chemical structure
Properties
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Chemical name
2-[3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl]-5-ethyl-2,4-dihydro-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one hydrochloride -
Molecular weight
506.47 -
Molecular formula
C25H32ClN5O2.HCl -
PubChem identifier
54911 -
Storage instructions
Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 25 mM, in ethanol to 10 mM and in 1 eq. HCl to 10 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Cl.Clc1cccc(c1)N4CCN(CCCN3N=C(CC)N(CCOc2ccccc2)C3=O)CC4 -
Source
Synthetic
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Research areas
- Epigenetics and Nuclear Signaling
- Nuclear Signaling Pathways
- Nuclear Receptors
- Orphan Nuclear Receptors
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Nucleotide metabolism
- Molecular processes
- Mitochondrial transcription
Images
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Chemical Structure - Nefazodone hydrochloride, 5-HT2A antagonist (ab120587)2D chemical structure image of ab120587, Nefazodone hydrochloride, 5-HT2A antagonist
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (0)
ab120587 has not yet been referenced specifically in any publications.