NG-Monomethyl-L-arginine, monoacetate salt (L-NMMA), NOS inhibitor (ab120137)
Key features and details
- NOS inhibitor
- CAS Number: 53308-83-1
- Soluble in water to 50 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
NG-Monomethyl-L-arginine, monoacetate salt (L-NMMA), NOS inhibitor -
Description
NOS inhibitor -
Alternative names
- L-NMMA
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Biological description
Cell-permeable competitive NOS inhibitor. (Ki values are 700 nM, 3.9 µM and 650 nM for eNOS, iNOS and nNOS, respectively).
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CAS Number
53308-83-1 -
Chemical structure
Properties
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Chemical name
NG-Methyl-L-arginine acetate -
Molecular weight
248.28 -
Molecular formula
C7H16N4O2.CH3CO2H -
PubChem identifier
135242 -
Storage instructions
Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 50 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
N[C@@H](CCCNC(=N)NC)C(=O)O.CC(=O)O -
Source
Synthetic
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Research areas
- Biochemicals
- Pharmacology
- Signaling
- Signal transduction
- Nitric oxide & oxidative stress
- NOS
- Inhibitors
- Biochemicals
- Research Area
- Alzheimer's Disease
- Signaling
- Signal transduction
- Nitric oxide signaling
- NOS
- Inhibitors
- Biochemicals
- Research Area
- Diabetes
- Signaling
- Signal transduction
- Nitric oxide signaling
- NOS
- Inhibitors
- Biochemicals
- Research Area
- Hypertension
- Signaling
- Signal transduction
- Nitric oxide signaling
- NOS
- Inhibitors
- Biochemicals
- Research Area
- Obesity
- Signaling
- Signal transduction
- Nitric oxide signaling
- NOS
- Inhibitors
Images
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Chemical Structure - NG-Monomethyl-L-arginine, monoacetate salt (L-NMMA), NOS inhibitor (ab120137)2D chemical structure image of ab120137, NG-Monomethyl-L-arginine, monoacetate salt (L-NMMA), NOS inhibitor
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (7)
ab120137 has been referenced in 7 publications.
- Ebner J et al. Neuronal nitric oxide synthase regulation of calcium cycling in ventricular cardiomyocytes is independent of Cav1.2 channel modulation under basal conditions. Pflugers Arch 472:61-74 (2020). PubMed: 31822999
- Roselló-Busquets C et al. Nystatin Regulates Axonal Extension and Regeneration by Modifying the Levels of Nitric Oxide. Front Mol Neurosci 13:56 (2020). PubMed: 32317932
- Devarakonda CV et al. CD13 deficiency leads to increased oxidative stress and larger atherosclerotic lesions. Atherosclerosis 287:70-80 (2019). PubMed: 31229835
- Lim SY et al. A New Neolignan Derivative, Balanophonin Isolated from Firmiana simplex Delays the Progress of Neuronal Cell Death by Inhibiting Microglial Activation. Biomol Ther (Seoul) 25:519-527 (2017). PubMed: 28554197
- Lood C et al. Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease. Nat Med N/A:N/A (2016). PubMed: 26779811
- Liu G et al. Targeting S1P1 receptor protects against murine immunological hepatic injury through myeloid-derived suppressor cells. J Immunol 192:3068-79 (2014). PubMed: 24567529
- Liu X et al. Calcium channels in rat horizontal cells regulate feedback inhibition of photoreceptors through an unconventional GABA- and pH-sensitive mechanism. J Physiol 591:3309-24 (2013). PubMed: 23613534
