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    products/biochemicals/nifedipine-l-type-ca2-channel-blocker-ab120135.pdf

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Biochemicals Chemical Type Biochemicals
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Nifedipine, L-type Ca2+ channel blocker (ab120135)

  • Datasheet
  • SDS
  • COA
Submit a review Submit a question References (11)

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Chemical Structure - Nifedipine, L-type Ca<sup>2+</sup> channel blocker (ab120135)
  • Functional Studies - Nifedipine, L-type Ca<sup>2+</sup> channel blocker (ab120135)

Key features and details

  • L-type Ca2+ channel blocker
  • CAS Number: 21829-25-4
  • Soluble in DMSO to 100 mM
  • Form / State: Solid
  • Source: Synthetic

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Overview

  • Product name

    Nifedipine, L-type Ca2+ channel blocker
  • Description

    L-type Ca2+ channel blocker
  • Biological description

    L-type Ca2+ channel blocker. Potent, long-acting vasodilator. Also shown to inhibit vascular inflammation.

  • CAS Number

    21829-25-4
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid dimethyl ester
  • Molecular weight

    346.34
  • Molecular formula

    C17H18N2O6
  • PubChem identifier

    4485
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Refer to SDS for further information

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC=1NC(C)=C(C(C=1C(=O)OC)c2ccccc2[N+]([O-])=O)C(=O)OC
  • Source

    Synthetic

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Applications

The Abpromise guarantee

Our Abpromise guarantee covers the use of ab120135 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Functional Studies
Use at an assay dependent concentration.
Notes
Functional Studies
Use at an assay dependent concentration.

Images

  • Chemical Structure - Nifedipine, L-type Ca<sup>2+</sup> channel blocker (ab120135)
    Chemical Structure - Nifedipine, L-type Ca2+ channel blocker (ab120135)
    2D chemical structure image of ab120135, Nifedipine, L-type Ca2+ channel blocker
  • Functional Studies - Nifedipine, L-type Ca<sup>2+</sup> channel blocker (ab120135)
    Functional Studies - Nifedipine, L-type Ca2+ channel blocker (ab120135)
    ab2770 staining aryl hydrocarbon receptor in MDA-MB-231 cells treated with nifedipine (ab120135), by ICC/IF. Increase in aryl hydrocarbon receptor expression correlates with increased concentration of nifedipine, as described in literature.
    The cells were incubated at 37°C for 6h in media containing different concentrations of ab120135 (nifedipine) in DMSO, fixed with 100% methanol for 5 minutes at -20°C and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab2770 (1/100 dilution) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-mouse polyclonal antibody (ab96879) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

Datasheets and documents

  • SDS download

  • Datasheet download

    Download
  • COA

References (11)

Publishing research using ab120135? Please let us know so that we can cite the reference in this datasheet.

ab120135 has been referenced in 11 publications.

  • Wang T  et al. Allopregnanolone Modulates GABAAR-Dependent CaMKIId3 and BDNF to Protect SH-SY5Y Cells Against 6-OHDA-Induced Damage. Front Cell Neurosci 13:569 (2019). PubMed: 31998078
  • Zhang F & Tzanakakis ES Optogenetic regulation of insulin secretion in pancreatic ß-cells. Sci Rep 7:9357 (2017). PubMed: 28839233
  • Favuzzi E  et al. Activity-Dependent Gating of Parvalbumin Interneuron Function by the Perineuronal Net Protein Brevican. Neuron 95:639-655.e10 (2017). PubMed: 28712654
  • Toft-Bertelsen TL  et al. Regulation of Ca2+ channels by SNAP-25 via recruitment of syntaxin-1 from plasma membrane clusters. Mol Biol Cell 27:3329-3341 (2016). PubMed: 27605709
  • Ahmed T  et al. Rescue of impaired late-phase long-term depression in a tau transgenic mouse model. Neurobiol Aging 36:730-9 (2015). PubMed: 25443285
View all Publications for this product

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