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    products/biochemicals/nimodipine-l-type-ca2-channel-blocker-ab120138.pdf

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Nimodipine, L-type Ca2+ channel blocker (ab120138)

  • Datasheet
  • SDS
  • COA
Submit a review Q&A (1)References (4)

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Chemical Structure - Nimodipine, L-type Ca<sup>2+</sup> channel blocker (ab120138)
  • Functional Studies - Nimodipine, L-type Ca<sup>2+</sup> channel blocker (ab120138)

Key features and details

  • L-type Ca2+ channel blocker
  • CAS Number: 66085-59-4
  • Soluble in DMSO to 100 mM and in ethanol to 10 mM
  • Form / State: Solid
  • Source: Synthetic

Overview

  • Product name

    Nimodipine, L-type Ca2+ channel blocker
  • Description

    L-type Ca2+ channel blocker
  • Biological description

    L-type Ca2+ channel blocker. Potent cerebrovasodilator. Cognitive enhancer. More lipophilic than nifedipine (ab120135).

  • General notes

    Nimodipine is light sensitive and it is recommended that the compound is protected from light.

  • CAS Number

    66085-59-4
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl 1-methylethyl ester
  • Molecular weight

    418.44
  • Molecular formula

    C21H26N2O7
  • PubChem identifier

    4497
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM and in ethanol to 10 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Toxic, refer to SDS for further information

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC=1NC(C)=C(C(C=1C(=O)OC(C)C)c2cccc(c2)[N+]([O-])=O)C(=O)OCCOC
  • Source

    Synthetic

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Applications

The Abpromise guarantee

Our Abpromise guarantee covers the use of ab120138 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Functional Studies
Use at an assay dependent concentration.
Notes
Functional Studies
Use at an assay dependent concentration.

Images

  • Chemical Structure - Nimodipine, L-type Ca<sup>2+</sup> channel blocker (ab120138)
    Chemical Structure - Nimodipine, L-type Ca2+ channel blocker (ab120138)
    2D chemical structure image of ab120138, Nimodipine, L-type Ca2+ channel blocker
  • Functional Studies - Nimodipine, L-type Ca<sup>2+</sup> channel blocker (ab120138)
    Functional Studies - Nimodipine, L-type Ca2+ channel blocker (ab120138)
    ab2770 staining aryl hydrocarbon receptor in MDA-MB-231 cells treated with nimodipine (ab120138), by ICC/IF. Increase in aryl hydrocarbon receptor expression correlates with increased concentration of nimodipine, as described in literature.
    The cells were incubated at 37°C for 6h in media containing different concentrations of ab120138 (nimodipine) in DMSO, fixed with 100% methanol for 5 minutes at -20°C and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab2770 (1/100 dilution) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-mouse polyclonal antibody (ab96879) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

Datasheets and documents

  • SDS download

  • Datasheet download

    Download
  • COA

References (4)

Publishing research using ab120138? Please let us know so that we can cite the reference in this datasheet.

ab120138 has been referenced in 4 publications.

  • Pousinha PA  et al. The Amyloid Precursor Protein C-Terminal Domain Alters CA1 Neuron Firing, Modifying Hippocampus Oscillations and Impairing Spatial Memory Encoding. Cell Rep 29:317-331.e5 (2019). PubMed: 31597094
  • Han KS  et al. Ephaptic Coupling Promotes Synchronous Firing of Cerebellar Purkinje Cells. Neuron 100:564-578.e3 (2018). PubMed: 30293822
  • Cohen SM  et al. Evolutionary and functional perspectives on signaling from neuronal surface to nucleus. Biochem Biophys Res Commun 460:88-99 (2015). PubMed: 25998737
  • Wheeler DG  et al. Ca(V)1 and Ca(V)2 channels engage distinct modes of Ca(2+) signaling to control CREB-dependent gene expression. Cell 149:1112-24 (2012). PubMed: 22632974

Customer reviews and Q&As

Show All Reviews Q&A
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Question

I have a technical question concerning nimodipine (Product code: ab120138, formerly Asc-138): Is this compound delivered as a racemate or is it one of the two enantiomers?

Read More

Abcam community

Verified customer

Asked on Jan 18 2012

Answer

Thank you for contacting us. We can confirm that ab120138 (formerly Asc-138) Nimodipine is a racemic mixture. I hope this helps, please let me know if you need any additional information.

Read More

Abcam Scientific Support

Answered on Jan 18 2012

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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