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    products/biochemicals/nitrendipine-l-type-ca2-channel-blocker-ab120139.pdf

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Nitrendipine, L-type Ca2+ channel blocker (ab120139)

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  • COA
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Chemical Structure - Nitrendipine, L-type Ca<sup>2+</sup> channel blocker (ab120139)
  • Functional Studies - Nitrendipine, L-type Ca<sup>2+</sup> channel blocker (ab120139)

Key features and details

  • L-type Ca2+ channel blocker
  • CAS Number: 39562-70-4
  • Soluble in DMSO to 50 mM and in ethanol to 25 mM
  • Form / State: Solid
  • Source: Synthetic

Overview

  • Product name

    Nitrendipine, L-type Ca2+ channel blocker
  • Description

    L-type Ca2+ channel blocker
  • Biological description

    L-type Ca2+ channel blocker. Antihypertensive in vivo.

  • CAS Number

    39562-70-4
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid ethyl methyl ester
  • Molecular weight

    360.36
  • Molecular formula

    C18H20N2O6
  • PubChem identifier

    4507
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 50 mM and in ethanol to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Refer to SDS for further information

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC=1NC(C)=C(C(C=1C(=O)OCC)c2cccc(c2)[N+]([O-])=O)C(=O)OC
  • Source

    Synthetic

  • Research areas

    • Cardiovascular
    • Angiogenesis
    • Cytokines
    • Other
    • Neuroscience
    • Neurotransmission
    • Receptors / Channels
    • Potassium Channels
    • Neuroscience
    • Neurotransmission
    • Receptors / Channels
    • Sodium Channels
    • Neuroscience
    • Neurology process
    • Neurodegenerative disease
    • Parkinson's disease
    • Parkin / PARK
    • Neuroscience
    • Neurotransmission
    • Receptors / Channels
    • GPCR
    • More GPCR
    • Neuroscience
    • Neurotransmission
    • Calcium Signaling
    • Calcium Channels
    • L-type
    • Immunology
    • Adaptive Immunity
    • MHC
    • Class I
    • Immunology
    • Innate Immunity
    • Cytokines
    • Interferons
    • Epigenetics and Nuclear Signaling
    • DNA / RNA
    • DNA Synthesis
    • Topoisomerases
    • Cell Biology
    • Proteolysis / Ubiquitin
    • Proteasome / Ubiquitin
    • Ubiquitin E3 Enzymes
    • RING Finger E3 Ligase
    • Neuroscience
    • Neurotransmission
    • Receptors / Channels
    • More Ion Channels
    • Signal Transduction
    • Signaling Pathway
    • Calcium Signaling
    • Calcium Channels
    • Signal Transduction
    • Signaling Pathway
    • G Protein Signaling
    • GPCR
    • Signal Transduction
    • Signaling Pathway
    • Nuclear Signaling
    • Nuclear Hormone Receptors
    • Testosterone
    • Signal Transduction
    • Growth Factors/Hormones
    • Hormones
    • Signal Transduction
    • Metabolism
    • Plasma Membrane
    • Channels
    • Neuroscience
    • Sensory System
    • Visual system
    • Neuroscience
    • Sensory System
    • Somatosensory system
    • Nociception
    • Epigenetics and Nuclear Signaling
    • Nuclear Signaling Pathways
    • Nuclear Receptors
    • Testosterone
    • Epigenetics and Nuclear Signaling
    • Transcription
    • Transcription Factors
    • Epigenetics and Nuclear Signaling
    • Nuclear Signaling Pathways
    • Nuclear Receptors
    • Orphan Nuclear Receptors
    • Signal Transduction
    • Metabolism
    • Lipid metabolism
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    • Drug metabolism
    • Cancer
    • Signal transduction
    • Nuclear signaling
    • Nuclear hormone receptors
    • Other
    • Cancer
    • Tumor immunology
    • Cytokines
    • Interferons
    • Cardiovascular
    • Atherosclerosis
    • Ischemia / Reperfusion
    • Cardiovascular
    • Blood
    • Blood Pressure regulation
    • Cardiovascular
    • Heart
    • Cardiac metabolism
    • Cardiovascular
    • Heart
    • Cardiac arrhythmias
    • Cardiovascular
    • Lipids / Lipoproteins
    • Fatty Acids
    • Metabolism
    • Developmental Biology
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    • Integration of energy metabolism
    • Biochemicals
    • Chemical Type
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    • Pharmacology
    • Ion Channels
    • Calcium
    • Blockers
    • Biochemicals
    • Pharmacology
    • Signaling
    • Ca2+ signaling
    • Cav channels
    • Biochemicals
    • Research Area
    • Heart disease
    • Calcium
    • Metabolism
    • Pathways and Processes
    • Mitochondrial Metabolism
    • Mitophagy fission and fusion
    • Metabolism
    • Pathways and Processes
    • Metabolic signaling pathways
    • Lipid and lipoprotein metabolism
    • Lipid metabolism
    • Metabolism
    • Pathways and Processes
    • Metabolic signaling pathways
    • Lipid and lipoprotein metabolism
    • Fatty acids
    • Metabolism
    • Pathways and Processes
    • Metabolic signaling pathways
    • Drug metabolism
    • Metabolism
    • Pathways and Processes
    • Metabolic signaling pathways
    • Energy transfer pathways
    • Integration of energy
    • Metabolism
    • Types of disease
    • Heart disease
    • Biochemicals
    • Research Area
    • Heart disease
    • Signaling
    • Ca2+ signaling
    • Cav channels
    • Biochemicals
    • Research Area
    • Pain & inflammation
    • Signaling
    • Ca2+ signaling
    • Cav channels
    • Biochemicals
    • Research Area
    • Alzheimer's Disease
    • Signaling
    • Ca2+ signaling
    • Cav channels
    • Biochemicals
    • Research Area
    • Diabetes
    • Ca2+ signaling
    • Cav channels
    • Biochemicals
    • Research Area
    • Diabetes
    • Signaling
    • Ca2+ signaling
    • Cav channels
    • Biochemicals
    • Research Area
    • Heart disease
    • Ca2+ signaling
    • Cav channels
    • Biochemicals
    • Research Area
    • Hypertension
    • Ca2+ signaling
    • Cav channels
    • Biochemicals
    • Research Area
    • Hypertension
    • Signaling
    • Ca2+ signaling
    • Cav channels
    • Biochemicals
    • Research Area
    • Obesity
    • Ca2+ signaling
    • Cav channels
    • Biochemicals
    • Research Area
    • Obesity
    • Signaling
    • Ca2+ signaling
    • Cav channels
    • Biochemicals
    • Research Area
    • Pain & inflammation
    • Ca2+ signaling
    • Cav channels
    • Biochemicals
    • Research Area
    • Respiratory disease
    • Ca2+ signaling
    • Cav channels
    • Biochemicals
    • Research Area
    • Respiratory disease
    • Signaling
    • Ca2+ signaling
    • Cav channels
    • Biochemicals
    • Research Area
    • Stroke
    • Ca2+ signaling
    • Cav channels
    • Biochemicals
    • Research Area
    • Stroke
    • Signaling
    • Ca2+ signaling
    • Cav channels
    • Biochemicals
    • Research Area
    • Cancer
    • Ca2+ signaling
    • Cav channels

Applications

The Abpromise guarantee

Our Abpromise guarantee covers the use of ab120139 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Functional Studies
Use at an assay dependent concentration.
Notes
Functional Studies
Use at an assay dependent concentration.

Images

  • Chemical Structure - Nitrendipine, L-type Ca<sup>2+</sup> channel blocker (ab120139)
    Chemical Structure - Nitrendipine, L-type Ca2+ channel blocker (ab120139)
    2D chemical structure image of ab120139, Nitrendipine, L-type Ca2+ channel blocker
  • Functional Studies - Nitrendipine, L-type Ca<sup>2+</sup> channel blocker (ab120139)
    Functional Studies - Nitrendipine, L-type Ca2+ channel blocker (ab120139)
    ab2770 staining aryl hydrocarbon receptor in MDA-MB-231 cells treated with nitrendipine (ab120139), by ICC/IF. Increase in aryl hydrocarbon receptor expression correlates with increased concentration of nitrendipine, as described in literature.
    The cells were incubated at 37°C for 6h in media containing different concentrations of ab120139 (nitrendipine) in DMSO, fixed with 100% methanol for 5 minutes at -20°C and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab2770 (1/100 dilution) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-mouse polyclonal antibody (ab96879) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

Datasheets and documents

  • SDS download

  • Datasheet download

    Download
  • COA

References (0)

Publishing research using ab120139? Please let us know so that we can cite the reference in this datasheet.

ab120139 has not yet been referenced specifically in any publications.

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