NSC 23766 trihydrochloride, Rac-1 inhibitor (ab142161)
Key features and details
- Selective Rac-1 inhibitor
- CAS Number: 1177865-17-6
- Purity: > 98%
- Soluble in water to 100 mM and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
NSC 23766 trihydrochloride, Rac-1 inhibitor -
Description
Selective Rac-1 inhibitor -
Biological description
Selective Rac-1 inhibitor. Blocks Rac-specific guanine nucleotide exchange factors TrioN and Tiam1 (IC50 = 50 μM) without affecting Cdc42 or RhoA activation. Apoptotic and causes G1 cell cycle arrest in vitro. Cell-permeable. Active in vivo and centrally active.
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Purity
> 98% -
CAS Number
1177865-17-6 -
Chemical structure
Properties
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Chemical name
N6-[2-[[4-(Diethylamino)-1-methylbutyl]amino]-6-methyl-4-pyrimidinyl]-2-methyl-4,6-quinolinediamine trihydrochloride -
Molecular weight
530.97 -
Molecular formula
C24H35N7.3HCl -
PubChem identifier
16759159 -
Storage instructions
Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 100 mM and in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CCN(CC)CCCC(C)NC1=NC(=CC(=N1)NC2=CC3=C(C=C2)N=C(C=C3N)C)C.Cl.Cl.Cl -
Source
Synthetic
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Research areas
Images
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Chemical Structure - NSC 23766 trihydrochloride, Rac-1 inhibitor (ab142161)2D chemical structure image of ab142161, NSC 23766 trihydrochloride, Rac-1 inhibitor
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (3)
ab142161 has been referenced in 3 publications.
- Hiratsuka K et al. Organoid-on-a-chip model of human ARPKD reveals mechanosensing pathomechanisms for drug discovery. Sci Adv 8:eabq0866 (2022). PubMed: 36129975
- Xie N et al. MicroRNA-142-3p suppresses cell proliferation, invasion and epithelial-to-mesenchymal transition via RAC1-ERK1/2 signaling in colorectal cancer. Mol Med Rep 24:N/A (2021). PubMed: 34109430
- Kolyvushko O et al. Equine Alphaherpesviruses Require Activation of the Small GTPases Rac1 and Cdc42 for Intracellular Transport. Microorganisms 8:N/A (2020). PubMed: 32645930