Pam3Cys-Ser-(Lys)4, TLR1/TLR2 agonist (ab142085)
Key features and details
- TLR1/TLR2 agonist
- CAS Number: 112208-00-1
- Purity: > 95%
- Soluble in 1:1 water/ethanol to 1 mg/ml
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Pam3Cys-Ser-(Lys)4, TLR1/TLR2 agonist -
Description
TLR1/TLR2 agonist -
Alternative names
- pam3CSK4
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Biological description
TLR1/TLR2 agonist. Synthetic analog of the triacylated N-terminal part of bacterial lipoproteins. Potent adjuvant in vivo. Potent activator of Balb/c splenocytes.
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Purity
> 95% -
CAS Number
112208-00-1 -
Chemical structure
Properties
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Molecular weight
1510.24 -
Molecular formula
C81H156N10O13S -
Sequence
CSKKKK (Modifications: N-terminal palmitoyl; Cys-1 = Cys(2,3-Bis(palmitoyloxy)propyl)) -
PubChem identifier
130704 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in 1:1 water/ethanol to 1 mg/ml -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O -
Source
Synthetic
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Research areas
Images
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Chemical Structure - Pam3Cys-Ser-(Lys)4, TLR1/TLR2 agonist (ab142085)2D chemical structure image of ab142085, Pam3Cys-Ser-(Lys)4, TLR1/TLR2 agonist
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (7)
ab142085 has been referenced in 7 publications.
- Ma D et al. Toll-like Receptor 2 is Involved in Calcium Influx and Acrosome Reaction to Facilitate Sperm Penetration to Oocytes During in vitro Fertilization in Cattle. Front Cell Dev Biol 10:810961 (2022). PubMed: 35281105
- Liu ZM et al. Suramin attenuates intervertebral disc degeneration by inhibiting NF-?B signalling pathway. Bone Joint Res 10:498-513 (2021). PubMed: 34372688
- Elesh IF et al. Peptidoglycan Switches Off the TLR2-Mediated Sperm Recognition and Triggers Sperm Localization in the Bovine Endometrium. Front Immunol 11:619408 (2020). PubMed: 33643300
- Ezz MA et al. TLR2/4 signaling pathway mediates sperm-induced inflammation in bovine endometrial epithelial cells in vitro. PLoS One 14:e0214516 (2019). PubMed: 30995239
- Shen Q et al. TLR2 protects cisplatin-induced acute kidney injury associated with autophagy via PI3K/Akt signaling pathway. J Cell Biochem 120:4366-4374 (2019). PubMed: 30387162
- Maatouk L et al. TLR9 activation via microglial glucocorticoid receptors contributes to degeneration of midbrain dopamine neurons. Nat Commun 9:2450 (2018). PubMed: 29934589
- Hussain T et al. MicroRNA 27a-3p Regulates Antimicrobial Responses of Murine Macrophages Infected by Mycobacterium avium subspecies paratuberculosis by Targeting Interleukin-10 and TGF-ß-Activated Protein Kinase 1 Binding Protein 2. Front Immunol 8:1915 (2017). PubMed: 29375563